TRIFLURIDINE
Sponsors
Merck Sharp & Dohme LLC, Universitaetsklinikum Heidelberg AöR, Gruppo Oncologico Del Nord Ovest, Association Gercor, AbbVie Deutschland GmbH & Co. KG
Conditions
Advanced Solid TumorsColorectal CancerHIV InfectionsHerpes SimplexMetastatic Colorectal CancerMetastatic Colorectal cancer (mCRC)Mycobacterium Avium-Intracellulare InfectionStage III and high-risk stage II resected colon cancer patients.
Phase 1
Phase 2
A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations
TerminatedNCT04854434
Start: 2021-06-29End: 2022-06-24Updated: 2023-11-03
A randomized, open label, multicenter phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic, refractory colorectal cancer patients (TROPHIT1)
Active, not recruitingCTIS2023-509771-17-00
Start: 2024-06-04Target: 80Updated: 2025-01-21
Exploiting circulating tumour DNA to intensify the postoperative treatment of stage III and high-risk stage II resected colon cancer patients with adjuvant FOLFOXIRI and/or post-adjuvant Trifluridine/Tipiracil. ERASE-CRC
SuspendedCTIS2024-515152-20-00
Start: 2023-03-02Target: 477Updated: 2024-11-25
BEvacizumab plus Trifluridine/tipiracil in a bi-WEEkly administration to reduce grade 3-4 Neutropenia in patients with mCRC: A prospective, multicenter, comparative, randomized GERCOR G-124 BETWEEN phase II study
Not yet recruitingCTIS2024-520128-27-00
Target: 162Updated: 2025-10-20
Phase 3
A Phase 3 study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Standard of Care in Previously Treated Metastatic PD-L1 positive Colorectal Cancer (KEYFORM-007)
CompletedCTIS2024-511043-25-00
Start: 2021-11-30End: 2025-02-21Target: 102Updated: 2025-02-04
A Phase 3, Multicenter, Open-label, Randomized Study to Compare the Efficacy and Safety of MK-2870 Versus Treatment of Physician’s Choice in 3L+ Advanced/Metastatic Gastroesophageal Adenocarcinoma (Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, and Esophageal Adenocarcinoma)
RecruitingCTIS2023-505423-31-00
Start: 2024-08-08Target: 115Updated: 2025-08-20
AndroMETa-CRC-560: An Open-Label, Randomized, Controlled, Global Phase 3 Study Comparing Telisotuzumab Adizutecan (ABBV-400) plus Bevacizumab to LONSURF (Trifluridine and Tipiracil) plus Bevacizumab in Subjects with Refractory Metastatic Colorectal Cancer
Not yet recruitingCTIS2025-521712-19-00
Target: 98Updated: 2026-06-30
Unknown Phase
Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
CompletedNCT00000635
End: 1992-04-30Target: 25Updated: 2021-11-02
Evaluation of the Therapeutic Benefit of r-metHuIFN- Gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
CompletedNCT00002037
Target: 15Updated: 2005-06-24