Tranylcypromine

DRUG13 trials

Conditions

AMLAcute Myelogenous LeukemiaAcute Myeloid LeukemiaAnxiety DisordersAutonomic FailureBipolar DisorderBipolar Disorder I or IIDementia

Phase 1

Treatment of Orthostatic Hypotension in Autonomic Failure

CompletedNCT00223691

Vanderbilt UniversityAutonomic Failure, Orthostatic Hypotension

Start: 2002-03-31End: 2017-01-31Updated: 2017-01-18

Bioavailability Study of Tranylcypromine 10mg Tablets Under Fasting Conditions

CompletedNCT00653393

Par Pharmaceutical, Inc.To Determine the Bioavailability of Tranylcypromine

Start: 2004-10-31End: 2004-12-31Updated: 2008-04-04

Phase I/II Trial of ATRA and TCP in Patients With Relapsed or Refractory AML and no Intensive Treatment is Possible

NCT02261779

Martin-Luther-Universität Halle-WittenbergAML

Start: 2014-09-30End: 2017-09-30Target: 16Updated: 2015-07-07

Study of TCP-ATRA for Adult Patients With AML and MDS

CompletedNCT02273102

University of MiamiAcute Myelogenous Leukemia, Leukemia, Myelodysplastic Syndromes

Start: 2015-03-02End: 2020-07-01Updated: 2020-07-21

Study of Sensitization of Non-M3 AML Blasts to ATRA by Epigenetic Treatment With Tranylcypromine (TCP)

NCT02717884

Michael LuebbertAcute Myeloid Leukemia, Myelodysplastic Syndrome

Start: 2015-05-31End: 2021-12-31Target: 60Updated: 2018-10-18

Phase 3

Pharmacovigilance in Gerontopsychiatric Patients

TerminatedNCT02374567

Hannover Medical SchoolAnxiety Disorders, Dementia, Depression +2

Start: 2015-01-31End: 2017-06-28Updated: 2018-02-28

Phase 4

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

CompletedNCT00021528

National Institute of Mental Health (NIMH)Depression

Start: 2001-07-31End: 2006-09-30Target: 4000Updated: 2009-09-25

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

CompletedNCT00177567

University of PittsburghBipolar Disorder

Start: 2001-07-31End: 2004-01-31Target: 60Updated: 2005-09-15

Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depression

TerminatedNCT00296686

New York State Psychiatric InstituteMajor Depression

Start: 2001-09-30End: 2006-08-31Updated: 2012-04-27

PET Biomarkers in Treatment Resistant Depression

TerminatedNCT01031810

New York State Psychiatric InstituteMajor Depressive Disorder

Start: 2009-11-30End: 2013-03-31Updated: 2014-09-18

Tranylcypromine Treatment of Bipolar Depression

CompletedNCT01430455

New York State Psychiatric InstituteBipolar Disorder I or II

Start: 2011-11-30End: 2014-09-30Updated: 2018-03-15

Unknown Phase

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

CompletedNCT00012558

National Institute of Mental Health (NIMH)Bipolar Disorder

Start: 1998-09-30End: 2005-09-30Target: 5000Updated: 2007-05-04

Interpersonal Psychotherapy for Treatment Resistant Depression

NCT01896349

Hospital de Clinicas de Porto AlegreTreatment Resistant Depression

Start: 2013-04-30End: 2014-11-30Target: 74Updated: 2013-07-11

2026-01-15

SMARTs with treatment preference: Pragmatic SMART design and methods motivated by STAR*D.

2025-11-24

Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension

Hypertension2024-12-275 citations

Machine Learning Prediction of Quality of Life Improvement During Antidepressant Treatment of Patients With Major Depressive Disorder

The Journal of Clinical Psychiatry2023-11-102 citations

Phase I Study of the LSD1 Inhibitor Tranylcypromine (TCP) in Combination with All-<i>Trans</i> Retinoic Acid (ATRA) and Low-Dose Cytarabine (LDAC) in Elderly, Medically Non-Fit Patients with AML or High-Risk MDS (TRANSATRA trial)

Blood2022-11-159 citations

Predictors of the Pressor Response to the Norepinephrine Transporter Inhibitor, Atomoxetine, in Neurogenic Orthostatic Hypotension

Hypertension2021-06-2822 citations

Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies

Clinical Cancer Research2021-01-2545 citations

What to Expect When Switching to a Second Antidepressant Medication Following an Ineffective Initial SSRI

The Journal of Clinical Psychiatry2020-08-1018 citations

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Blood2018-11-2910 citations

Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study

The Journal of Clinical Psychiatry2017-08-2112 citations

A Case of AML Characterized by a Novel t(4;15)(q31;q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy

International Journal of Molecular Sciences2017-07-1114 citations

Early Improvement of Specific Symptoms Predicts Subsequent Recovery in Bipolar Depression

The Journal of Clinical Psychiatry2017-02-208 citations

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Blood2016-12-02

Time Course and Predictors of Suicidal Ideation During Citalopram Treatment in the STAR*D Trial

The Journal of Clinical Psychiatry2016-09-135 citations

Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension

Hypertension2016-06-0776 citations

Changes in depression subtypes for women during treatment with citalopram: a latent transition analysis.

2016-01-229 citations

Cross-trial prediction of treatment outcome in depression: a machine learning approach.

2016-01-21434 citations

Interpersonal psychotherapy as add-on for treatment-resistant depression: A pragmatic randomized controlled trial.

2016-01-0817 citations

Prevalence and Impact of Obsessive-Compulsive Symptoms in Depression

The Journal of Clinical Psychiatry2015-12-2122 citations

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

Blood2015-12-0316 citations

14 more papers not shown