Transoral robotic surgery

PROCEDURE16 trials

Sponsors

Kyoto University, Kitasato University, School of Medicine, Stanford University, Barbara Ann Karmanos Cancer Institute, University of Alabama at Birmingham

Conditions

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC (American Joint Committee on Cancer) v8Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8DysphagiaHPVHPV Positive Oropharyngeal Squamous Cell CarcinomaHPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Clinical StageHead and Neck Cancer

Phase 1

Transoral Robotic Surgery or Standard Surgery in Treating Patients With Benign or Malignant Tumors of the Larynx and Pharynx

CompletedNCT00918762

Barbara Ann Karmanos Cancer InstituteHead and Neck Cancer, Perioperative/Postoperative Complications, Precancerous Condition

Start: 2009-05-31End: 2010-10-31Updated: 2014-05-09

Muti instuitutional clinical study of transoral robotic surgery for laryngopharyngeal cancer - a pilot study -

Active, not recruitingJPRN-UMIN000012139

Kyoto UniversityLaryngopharyngeal cancer

Start: 2013-12-01Target: 7Updated: 2025-07-18

Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner

TerminatedNCT03618134

Jonsson Comprehensive Cancer CenterClinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC (American Joint Committee on Cancer) v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 +6

Start: 2018-10-04End: 2023-06-30Updated: 2023-11-18

TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers

Not yet recruitingNCT05108870

University of ChicagoHead and Neck Cancer, HPV, HPV Positive Oropharyngeal Squamous Cell Carcinoma +1

Start: 2026-07-17End: 2027-01-01Target: 98Updated: 2026-03-25

Phase 2

Muti instuitutional clinical study of transoral robotic surgery for laryngopharyngeal cancer

RecruitingJPRN-UMIN000012149

Kyoto UniversityLaryngopharyngeal cancer

Start: 2015-02-01Target: 20Updated: 2025-07-18

Unknown Phase

Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive Tract

TerminatedNCT00721539

Stanford UniversityHead and Neck Cancers, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

Start: 2010-09-30End: 2012-09-30Updated: 2016-11-03

Prospective Study to Evaluate Outcomes From Transoral BOT Resection for OSAHS

TerminatedNCT01107795

University of Alabama at BirminghamObstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

Start: 2010-03-04End: 2019-07-26Updated: 2020-01-06

Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

TerminatedNCT01254734

City of Hope Medical CenterRecurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Lymphoepithelioma of the Nasopharynx, Recurrent Lymphoepithelioma of the Oropharynx +52

Start: 2011-04-30End: 2014-11-30Updated: 2014-11-10

Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

RecruitingNCT01473784

Ohio State University Comprehensive Cancer CenterRecurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Mucoepidermoid Carcinoma of the Oral Cavity, Recurrent Squamous Cell Carcinoma of the Hypopharynx +48

Start: 2007-12-03End: 2026-12-31Target: 600Updated: 2026-02-10

Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer

CompletedNCT01748942

OHSU Knight Cancer InstituteDysphagia, Pain, Stage III Oropharyngeal Squamous Cell Carcinoma +2

Start: 2012-12-31End: 2017-03-29Updated: 2018-06-19

Efficacy and Safety of TORS for SCCA

Active, not recruitingNCT01819480

Katherine L FedderOropharyngeal Squamous Cell Carcinoma, Supraglottic Squamous Cell Carcinoma

Start: 2013-03-31End: 2025-12-31Target: 110Updated: 2024-02-09

Prospective, Multicenter da Vinci® SP™ Surgical System TORS Study

CompletedNCT03049280

Intuitive SurgicalOropharyngeal Cancer

Start: 2017-04-17End: 2017-12-26Updated: 2020-10-06

Evaluation of safety and efficacy of transoral robotic surgery for laryngo-pharyngeal cancer

Active, not recruitingJPRN-UMIN000036646

Kitasato University, School of MedicineLaryngo-pharyngeal cancer

Start: 2019-08-01Target: 30Updated: 2025-11-17

De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma

Active, not recruitingNCT04638465

Nebraska Methodist Health SystemHPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Clinical Stage, Oropharynx Cancer

Start: 2018-08-06End: 2030-01-31Target: 150Updated: 2023-11-09

Treatment of Obstructive Sleep Apnea (OSA) With the da Vinci® SP™ Surgical System

CompletedNCT04795817

Intuitive SurgicalObstructive Sleep Apnea

Start: 2021-01-27End: 2023-01-25Updated: 2023-05-31

Myofunctional Training for Obstructive Sleep Apnea Patients After Transoral Robotic Surgery

CompletedNCT04876482

National Cheng-Kung University HospitalSleep Apnea, Obstructive

Start: 2020-01-01End: 2022-12-31Updated: 2024-10-21

Related Papers

First Prospective Study on Single‐Port Robotic Tongue Base Resection for Sleep Apnea

Head & Neck2024-11-224 citations

Neoadjuvant HPV16-specific arenavirus-based immunotherapy HB-200 plus chemotherapy followed by response-stratified de-intensification in HPV16+ oropharyngeal cancer: TARGET-HPV.

Journal of Clinical Oncology2024-06-0110 citations

Quality of Life and Depression Symptoms After Therapy De-Escalation in HPV+ Oropharyngeal Squamous Cell Carcinoma

JAMA Otolaryngology–Head & Neck Surgery2024-04-041 citations

Randomized phase I/II trial of TheraT vectors expressing HPV16 specific antigens with neoadjuvant chemotherapy followed by transoral robotic surgery (TORS) or risk/response stratified chemoradiotherapy (CRT) for locoregional HPV16+ oropharyngeal cancer (OPC).

Journal of Clinical Oncology2023-06-01

A Next-Generation Single-Port Robotic Surgical System for Transoral Robotic Surgery

JAMA Otolaryngology–Head & Neck Surgery2019-09-1944 citations