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Tranilast

DRUG13 trials

Sponsors

Hirata Hitoshi, Imperial College London, Nuon Therapeutics, Inc., The First Affiliated Hospital with Nanjing Medical University, Peking Union Medical College Hospital

Conditions

Active Rheumatoid ArthritisCryopyrin-Associated Periodic SyndromesEsophageal NeoplasmsEsophageal StrictureGoutHyperuricemiaMucinosesNLRP3

Early Phase 1

A Clinical Study of Tranilast in the Treatment of Mucinoses
NCT03490708
The First Affiliated Hospital with Nanjing Medical UniversityMucinoses
Start: 2018-04-30End: 2022-12-31Target: 56Updated: 2018-04-06
A Clinical Study of Tranilast in the Treatment of Scleredema Diabeticorum
NCT03512873
The First Affiliated Hospital with Nanjing Medical UniversityScleredema Adultorum
Start: 2018-06-30End: 2020-12-31Target: 56Updated: 2018-05-01
A Clinical Study of Tranilast in the Treatment of Sarcoidosis
NCT03528070
The First Affiliated Hospital with Nanjing Medical UniversitySarcoidosis
Start: 2018-05-31End: 2020-12-31Target: 56Updated: 2018-05-17

Phase 1

Effects of Tranilast on Pharmacokinetics of Methotrexate (MTX) in Patients With Rheumatoid Arthritis (RA)
WithdrawnNCT00717808
Imperial College LondonRheumatoid Arthritis
Start: 2008-09-30End: 2009-09-30Updated: 2015-05-28

Phase 2

Safety and Efficacy Study of Tranilast in Patients With Active Rheumatoid Arthritis (RA)
CompletedNCT00882024
Nuon Therapeutics, Inc.Active Rheumatoid Arthritis
Start: 2009-03-31End: 2010-12-31Target: 250Updated: 2011-01-06
Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia
CompletedNCT00995618
Nuon Therapeutics, Inc.Gout, Hyperuricemia
Start: 2009-09-30End: 2010-04-30Updated: 2011-01-06
Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemia
CompletedNCT01052987
Nuon Therapeutics, Inc.Gout, Hyperuricemia
Start: 2010-01-31End: 2010-11-30Target: 24Updated: 2011-01-06
A Clinical Study of Tranilast in the Treatment of Cryopyrin-Associated Periodic Syndrome (CAPS)
NCT03923140
Peking Union Medical College HospitalCryopyrin-Associated Periodic Syndromes
Start: 2019-05-23End: 2024-10-31Target: 71Updated: 2019-06-04
Tranilast as a Radiosensitizer in Reradiation of Nasopharyngeal Carcinoma
NCT05626829
Jian GuanNasopharyngeal Carcinoma, Recurrent Cancer
Start: 2022-07-20End: 2024-11-30Target: 18Updated: 2023-10-06
Tranilast Vs. Steroids to Prevent Esophageal Stricture (TAPES) After Endoscopic Resection for Superficial Neoplasms
Not yet recruitingNCT06643689
Second Affiliated Hospital, School of Medicine, Zhejiang UniversityEsophageal Neoplasms, Esophageal Stricture
Start: 2025-01-01End: 2028-12-31Target: 394Updated: 2024-11-14

Phase 4

Effect of Inflammasome Inhibitor on hsCRP in Patients After PCI
CompletedNCT05130892
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyhsCRP, NLRP3, Percutaneous Coronary Intervention
Start: 2021-11-15End: 2023-02-01Updated: 2023-02-08
Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea
Enrolling by invitationNCT06307288
Second Affiliated Hospital of Xi'an Jiaotong UniversityRosacea
Start: 2023-10-16End: 2024-06-01Target: 45Updated: 2024-03-12

Unknown Phase

The efficacy of tranilast after carpal tunnel release; randomized controlled trial
Active, not recruitingJPRN-jRCTs041190049
Hirata Hitoshicarpal tunnel syndrome carpal tunnel syndrome
Start: 2019-06-26Target: 170Updated: 2026-06-29