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Tozorakimab-placebo

DRUG5 trials

Sponsors

AstraZeneca AB, Astrazeneca AB

Conditions

AsthmaChronic Obstructive Pulmonary Disease (COPD)Severe viral lung infections

Phase 2

Phase 3

A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
Active, not recruitingCTIS2023-505543-39-00
Astrazeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2024-02-12Target: 480Updated: 2026-01-26
A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
RecruitingCTIS2023-507031-38-00
Astrazeneca ABSevere viral lung infections
Start: 2023-01-09Target: 828Updated: 2026-01-09
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
Active, not recruitingCTIS2023-503571-19-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-01-20Target: 479Updated: 2025-11-13
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
Active, not recruitingCTIS2023-503572-24-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-03-02Target: 350Updated: 2025-10-30