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Tozorakimab

DRUG16 trials

Sponsors

Astrazeneca AB, AstraZeneca AB, AstraZeneca

Conditions

AsthmaChronic BronchitisChronic Obstructive Pulmonary Disease (COPD)Healthy ParticipantsSevere viral lung infectionsViral Lung Infection and Acute Respiratory Failure

Phase 1

Phase 2

Phase 3

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.
CompletedNCT05158387
AstraZenecaChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-02-07End: 2026-03-22Updated: 2026-04-16
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
CompletedNCT05166889
AstraZenecaChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-01-03End: 2026-03-11Updated: 2026-04-16
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
RecruitingNCT05624450
AstraZenecaViral Lung Infection and Acute Respiratory Failure
Start: 2022-12-13End: 2027-11-04Target: 3527Updated: 2026-08-28
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations (PROSPERO)
Active, not recruitingCTIS2022-501063-41-00
Astrazeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2023-04-20Target: 802Updated: 2026-01-19
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
CompletedNCT06040086
AstraZenecaChronic Obstructive Pulmonary Disease (COPD)
Start: 2023-09-22End: 2026-05-22Updated: 2026-07-24
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
Active, not recruitingCTIS2023-505543-39-00
Astrazeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2024-02-12Target: 480Updated: 2026-01-26
A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
RecruitingCTIS2023-507031-38-00
Astrazeneca ABSevere viral lung infections
Start: 2023-01-09Target: 828Updated: 2026-01-09
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
Active, not recruitingCTIS2023-503571-19-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-01-20Target: 479Updated: 2025-11-13
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
Active, not recruitingCTIS2023-503572-24-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2022-03-02Target: 350Updated: 2025-10-30
A phase III, Multicentre, Open-Label, Chronic dosing, Extension Study to Evaluate the Long-term Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (ROMEO)
Not yet recruitingCTIS2025-523690-41-00
AstraZeneca ABChronic Obstructive Pulmonary Disease (COPD)
Target: 82Updated: 2025-12-24

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