Tozorakimab
Sponsors
Astrazeneca AB, AstraZeneca AB, AstraZeneca
Conditions
AsthmaChronic BronchitisChronic Obstructive Pulmonary Disease (COPD)Healthy ParticipantsSevere viral lung infectionsViral Lung Infection and Acute Respiratory Failure
Phase 1
A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab Via Subcutaneous Administration in Healthy Volunteers
CompletedNCT06304961
Start: 2024-04-08End: 2024-09-09Updated: 2024-09-19
An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab
CompletedNCT06908577
Start: 2025-04-07End: 2025-11-25Updated: 2025-12-02
Phase 2
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis
CompletedNCT04631016
Start: 2020-12-14End: 2023-11-13Updated: 2025-02-27
A Study to Investigate Efficacy and Safety of Tozorakimab Injections Compared With Placebo in Adult Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations and Elevated Eosinophils
CompletedNCT06897748
Start: 2025-04-12End: 2026-04-21Updated: 2026-07-14
A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants with Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids (UMBRIEL)
RecruitingCTIS2024-519116-14-00
Start: 2025-05-27Target: 70Updated: 2026-01-19
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
RecruitingNCT06932263
Start: 2025-03-26End: 2028-02-28Target: 540Updated: 2026-07-20
Phase 3
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.
CompletedNCT05158387
Start: 2022-02-07End: 2026-03-22Updated: 2026-04-16
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
CompletedNCT05166889
Start: 2022-01-03End: 2026-03-11Updated: 2026-04-16
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
RecruitingNCT05624450
Start: 2022-12-13End: 2027-11-04Target: 3527Updated: 2026-08-28
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations (PROSPERO)
Active, not recruitingCTIS2022-501063-41-00
Start: 2023-04-20Target: 802Updated: 2026-01-19
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
CompletedNCT06040086
Start: 2023-09-22End: 2026-05-22Updated: 2026-07-24
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
Active, not recruitingCTIS2023-505543-39-00
Start: 2024-02-12Target: 480Updated: 2026-01-26
A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)
RecruitingCTIS2023-507031-38-00
Start: 2023-01-09Target: 828Updated: 2026-01-09
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
Active, not recruitingCTIS2023-503571-19-00
Start: 2022-01-20Target: 479Updated: 2025-11-13
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
Active, not recruitingCTIS2023-503572-24-00
Start: 2022-03-02Target: 350Updated: 2025-10-30
A phase III, Multicentre, Open-Label, Chronic dosing, Extension Study to Evaluate the Long-term Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (ROMEO)
Not yet recruitingCTIS2025-523690-41-00
Target: 82Updated: 2025-12-24