total neoadjuvant therapy

DRUG5 trials

Sponsors

Akiyoshi Takashi, Grupo Espanol Multidisciplinario del Cancer Digestivo, Jules Bordet Institute, St. James's Hospital, Ireland

Conditions

Locally Advanced Rectal CancerOlder PeoplePatients With Locally Advanced Rectal CancerRectal Cancerrectal cancer rectal cancer

Phase 2

RecruitingJPRN-jRCTs051200121

Akiyoshi Takashirectal cancer rectal cancer

Start: 2021-03-29Target: 224Updated: 2026-06-29

Non-operative Management after Chemoradiotherapy plus Sandwich (Induction and Consolidation with modified FOLFOXIRI) Chemotherapy in Patients with Locally Advanced Rectal Cancer: Multicenter Phase II Trial

RecruitingJPRN-jRCTs051250182

Akiyoshi Takashirectal cancer rectal cancer

Start: 2026-01-07Target: 75Updated: 2026-06-29

Phase 3

Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer

Not yet recruitingNCT06097416

St. James's Hospital, IrelandRectal Cancer

Start: 2024-10-31End: 2030-10-31Target: 100Updated: 2023-10-25

Unknown Phase

GEMCAD-REVEAL STUDY - Circulating Tumor DNA as a Predictor of Relapse in Patients With Locally Advanced Rectal Cancer.

Active, not recruitingNCT05674422

Grupo Espanol Multidisciplinario del Cancer DigestivoPatients With Locally Advanced Rectal Cancer

Start: 2023-05-26End: 2026-07-31Target: 120Updated: 2024-10-31

Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer

RecruitingNCT06052332

Jules Bordet InstituteLocally Advanced Rectal Cancer, Older People

Start: 2024-02-07End: 2033-12-31Target: 230Updated: 2025-12-05

Related Papers

Efficacy and safety of short-course radiotherapy versus total neoadjuvant therapy in older rectal cancer patients: a randomised pragmatic trial (SHAPERS)

ESMO Gastrointestinal Oncology2024-06-012 citations

Non-operative management after chemoradiotherapy plus consolidation or sandwich (induction with bevacizumab and consolidation) chemotherapy in patients with locally advanced rectal cancer: a multicentre, randomised phase II trial (NOMINATE trial)

BMJ Open2022-03-0112 citations