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Total Lymphoid Irradiation (TLI)

RADIATION8 trials

Sponsors

Stanford University, University of Michigan Rogel Cancer Center, Everett Meyer, St. Jude Children's Research Hospital

Conditions

Acute Myeloid LeukemiaAcute Myeloid Leukemia (AML)AnemiaAplastic AnemiaB-cell LymphomaBlood CancerBone Marrow Failure SyndromeBone Marrow Transplant Failure

Phase 2

Allogeneic Transplantation Using Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) for Older Patients With Hematologic Malignancies
CompletedNCT00185640
Stanford UniversityBlood Cancer, Leukemia
Start: 2003-03-31End: 2016-01-31Updated: 2021-06-29
TLI & ATG for Non-Myeloablative Allogeneic Transplantation for MDS and MPD
CompletedNCT00185796
Stanford UniversityBlood Cancer, Myelodysplastic Syndromes, Myeloproliferative Disorders
Start: 2004-07-31End: 2015-02-28Updated: 2015-03-18
Phase 2 Poor Risk DLBCL of TLI and ATG Followed by Matched Allogeneic HT as Consolidation to Autologous HCT
TerminatedNCT00482053
Stanford UniversityDiffuse Large B-cell Lymphoma (DLBCL), Lymphoma, B-cell, Lymphoma, Non-Hodgkin +1
Start: 2006-10-31End: 2010-05-31Updated: 2018-05-14
Trial Of Double Umbilical Cord Blood Transplantation
CompletedNCT00763490
University of Michigan Rogel Cancer CenterHematological Malignancies
Start: 2008-12-31End: 2015-10-31Updated: 2016-12-23
Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
CompletedNCT01392989
Everett MeyerAnemia, Bone Marrow Transplant Failure, Leukemia, Myeloid +3
Start: 2011-03-31End: 2017-03-19Updated: 2019-05-07
Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation
CompletedNCT03734601
Stanford UniversityAcute Myeloid Leukemia, B-cell Lymphoma, Chronic Lymphocytic Leukemia +6
Start: 2018-11-05End: 2020-11-17Updated: 2023-12-12
Haploidentical HCT for Severe Aplastic Anemia
RecruitingNCT04558736
St. Jude Children's Research HospitalAplastic Anemia, Bone Marrow Failure Syndrome
Start: 2021-01-21End: 2030-07-01Target: 21Updated: 2025-07-04

Phase 3

Allogeneic HCT Using Nonmyeloablative Host Conditioning With TLI & ATG vs SOC in AML
TerminatedNCT00568633
Stanford UniversityAcute Myeloid Leukemia (AML), Leukemia, Leukemia, Myeloid
Start: 2007-08-31End: 2015-12-31Updated: 2019-09-24

Related Papers

Donor-Derived Cytokine-Induced Killer Cell Infusion as Consolidation after Nonmyeloablative Allogeneic Transplantation for Myeloid Neoplasms
Biology of Blood and Marrow Transplantation2019-04-0222 citations
Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society.
2015-02-0637 citations
TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors.
2009-05-07125 citations