Total lymphoid irradiation

RADIATION17 trials

Sponsors

Masonic Cancer Center, University of Minnesota, Stanford University, University of Sao Paulo, M.D. Anderson Cancer Center, University of Michigan Rogel Cancer Center

Conditions

Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaBlood and Marrow Transplant (BMT)Diamond-Blackfan AnemiaGlomerulosclerosis, FocalHEMATOLOGIC MALIGNANCIESHematological MalignanciesHematopoietic Organs; Disorder

Phase 1

Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs

Active, not recruitingNCT00319657

Stanford UniversityImmune Tolerance

Start: 2004-07-31End: 2026-07-31Target: 15Updated: 2021-06-18

Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft

CompletedNCT00353535

University of Sao PauloGlomerulosclerosis, Focal

Start: 2000-01-31End: 2002-12-31Target: 10Updated: 2006-07-18

Study of Stem Cell Transplantation for Hematologic Malignancies Using Clofarabine and Busulfan Regimen

CompletedNCT00556452

University of Michigan Rogel Cancer CenterHodgkin Lymphoma, Leukemia, Multiple Myeloma +2

Start: 2007-10-31End: 2012-09-30Updated: 2017-12-05

Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.

RecruitingNCT03591302

Stephan BusqueImmune Tolerance

Start: 2024-02-02End: 2028-10-01Target: 25Updated: 2026-07-01

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

Active, not recruitingNCT05139004

City of Hope Medical CenterAcute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome +1

Start: 2022-07-19End: 2027-06-13Updated: 2026-07-06

TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation

Not yet recruitingNCT07634562

Stanford UniversityLiver Failure

Start: 2026-08-01End: 2031-08-01Target: 12Updated: 2026-06-09

Phase 2

Stem Cell Transplant for Bone Marrow Failure Syndromes

CompletedNCT00176878

Masonic Cancer Center, University of MinnesotaDiamond-Blackfan Anemia, Kostmann's Neutropenia, Shwachman-Diamond Syndrome

Start: 2000-06-30End: 2009-03-31Updated: 2017-12-28

Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD

CompletedNCT00186628

Stanford UniversityLeukemia, Mast-Cell, Mantle-cell Lymphoma

Start: 2005-06-30End: 2010-12-31Updated: 2017-11-28

Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma

TerminatedNCT00481832

Stanford UniversityLymphoma, Non-Hodgkin

Start: 2007-01-31End: 2017-03-30Updated: 2018-02-14

Reduced Intensity AlloTransplant For Osteopetrosis

TerminatedNCT00638820

Masonic Cancer Center, University of MinnesotaOsteopetrosis

Start: 2007-09-30End: 2008-05-31Updated: 2017-12-28

Allogeneic Transplantation For Severe Osteopetrosis

CompletedNCT00775931

Masonic Cancer Center, University of MinnesotaSevere Osteopetrosis

Start: 2008-08-31End: 2013-06-30Updated: 2019-07-31

Phase 2 Study of Autologous Followed by Nonmyeloablative Allogeneic Transplantation Using TLI & ATG

CompletedNCT00899847

Stanford UniversityBlood and Marrow Transplant (BMT), Multiple Myeloma, Transplantation, Autologous +1

Start: 2009-05-31End: 2014-12-31Updated: 2017-10-20

Haploidentical Donor Hematopoietic Progenitor Cell and NK Cell Transplantation for Hematologic Malignancy

CompletedNCT01807611

St. Jude Children's Research HospitalLeukemia, Lymphoma

Start: 2013-05-16End: 2021-09-27Updated: 2022-10-31

Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen

TerminatedNCT02199041

St. Jude Children's Research HospitalHematological Malignancies

Start: 2014-07-11End: 2017-05-23Updated: 2018-02-07

Unknown Phase

Thymoglobulin and Total Lymphoid Irradiation for Hematologic Malignancies

CompletedNCT00476229

M.D. Anderson Cancer CenterLeukemia, Lymphoma

Start: 2006-06-30End: 2009-05-31Updated: 2012-08-07

Total Lymphoid Irradiation and Anti-Thymocyte Globulin in the Allogeneic Hematopoietic Cell Transplantation

CompletedNCT01081405

Fondazione EMN Italy OnlusHEMATOLOGIC MALIGNANCIES

Start: 2007-11-30End: 2022-11-30Updated: 2024-03-13

Total Lymphoid Irradiation as Conditioning for Pediatric Haploidentical Hematopoietic Stem Cell Transplantation

RecruitingNCT06075563

Hong Kong Children's HospitalHematopoietic Organs; Disorder

Start: 2023-05-29End: 2026-12-31Target: 23Updated: 2025-09-10

Related Papers

First-in-human phase I trial combining radiopharmaceutical therapy (RPT) using a 90y-anti-CD25 monoclonal antibody (Mab) with total marrow and lymphoid irradiation (TMLI) in relapsed or refractory (R/R) acute leukemia

Blood2025-11-03

Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial.

2024-06-277 citations

CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

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Development of immunosuppressive myeloid cells to induce tolerance in solid organ and hematopoietic cell transplant recipients

Blood Advances2021-08-256 citations

Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies.

2011-08-1244 citations