FindTrial
Sign In

Tocilizumab (TCZ)

DRUG6 trials

Sponsors

Hoffmann-La Roche, National Institute of Allergy and Infectious Diseases (NIAID), Maria Stoenoiu, Wenjie Zheng, Insel Gruppe AG, University Hospital Bern

Conditions

Behcet SyndromeCOVID-19 PneumoniaNew-onset Type 1 Diabetes MellitusRheumatoid ArthritisSARS-CoV-2 InfectionT1DT1DMType 1 Diabetes Mellitus

Phase 2

Tocilizumab (TCZ) in New-onset Type 1 Diabetes
CompletedNCT02293837
National Institute of Allergy and Infectious Diseases (NIAID)New-onset Type 1 Diabetes Mellitus, T1D, T1DM +1
Start: 2015-03-12End: 2020-08-31Updated: 2021-09-08
Tocilizumab for the Treatment of Refractory Behcet's Uveitis
TerminatedNCT03554161
Wenjie ZhengBehcet Syndrome, Uveitis
Start: 2018-05-10End: 2021-02-01Updated: 2021-03-22
Tocilizumab in the Treatment of Coronavirus Induced Disease (COVID-19)
TerminatedNCT04335071
Insel Gruppe AG, University Hospital BernSARS-CoV-2 Infection
Start: 2020-04-26End: 2020-09-27Updated: 2020-10-14

Phase 3

A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTX
CompletedNCT01855789
Hoffmann-La RocheRheumatoid Arthritis
Start: 2013-11-07End: 2016-10-14Updated: 2017-12-26
Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid Arthritis
NCT02837146
Maria StoenoiuRheumatoid Arthritis
Start: 2015-12-31End: 2019-12-31Target: 45Updated: 2016-07-29
A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia
CompletedNCT04320615
Hoffmann-La RocheCOVID-19 Pneumonia
Start: 2020-04-03End: 2020-07-28Updated: 2021-06-30

Related Papers

Antibody profiling of COVID-19 patients reveals antibodies and autoantibodies that may be associated with faster recovery from COVID-19
The Journal of Immunology2024-05-01
Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis.
2022-12-0128 citations
Mesenchymal stem cell transplantation in newly diagnosed type-1 diabetes patients: a phase I/II randomized placebo-controlled clinical trial
Stem Cell Research & Therapy2022-06-20101 citations
Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA).
2022-04-2122 citations
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.
2021-11-0844 citations
Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients’
Cytokine2021-07-2932 citations
Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial.
2021-03-1753 citations
Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia
New England Journal of Medicine2021-02-251073 citations
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
Journal of Translational Medicine2020-10-21110 citations
A phase 2, open label, multicenter, single arm study of tocilizumab on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia (TOCIVID-19 trial): Statistical analysis plan
Contemporary Clinical Trials Communications2020-10-0715 citations
Interleukin-6 receptor blockade or TNFα inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials.
2020-09-0923 citations
Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study)
Clinical Cardiology2020-08-2448 citations
Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study.
2020-08-14210 citations
Horizontal transmission of severe acute respiratory syndrome coronavirus 2 to a premature infant: multiple organ injury and association with markers of inflammation
The Lancet Child & Adolescent Health2020-05-2029 citations
Perspective: Cell therapy, SARS‐CoV‐2, COVID‐19, and James Lind
Advances in Cell and Gene Therapy2020-05-112 citations
Immunotherapy during the COVID-19 pandemic
Cancer Research Statistics and Treatment2020-01-018 citations
Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
Science Translational Medicine2016-09-14103 citations
Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
The Journal of Immunology2016-05-016 citations