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TME surgery

PROCEDURE12 trials

Sponsors

UNICANCER, Zhongnan Hospital, Ruijin Hospital, Kyungpook National University Hospital, JIN JING

Conditions

Cancer of the RectumChemotherapyImmunotherapyLocally AdvancedLocally Advanced Gastric/Gastroesophageal Junction AdenocarcinomaLocally Advanced Rectal CancerLocally Advanced Rectal Cancer (LARC)Metastatic Colorectal Cancer (mCRC)

Phase 2

SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer
RecruitingNCT05576480
Ruijin HospitalLocally Advanced, Rectal Cancer
Start: 2023-02-06End: 2026-12-31Target: 55Updated: 2025-08-28
Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
Active, not recruitingNCT05673772
Kyungpook National University HospitalRectal Cancer
Start: 2020-10-23End: 2031-12-28Target: 364Updated: 2026-02-12
Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC(AK104-IIT-13)
Not yet recruitingNCT05794750
JIN JINGLocally Advanced Rectal Cancer
Start: 2023-04-24End: 2027-04-24Target: 50Updated: 2023-04-06
Node-sparing Radiotherapy Combined with Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer
RecruitingNCT06204094
Jinhua Central HospitalLocally Advanced Rectal Cancer
Start: 2024-02-05End: 2028-09-01Target: 37Updated: 2025-01-07
Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer
CompletedNCT06493240
Peking University People's HospitalLocally Advanced Rectal Cancer
Start: 2023-01-01End: 2025-04-01Updated: 2025-11-25
Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer
RecruitingNCT06802666
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyLocally Advanced Rectal Cancer, Neoadjuvant Therapy
Start: 2024-10-16End: 2027-12-30Target: 45Updated: 2025-01-31
Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Field I)
RecruitingNCT07057089
Hebei Medical University Fourth HospitalLocally Advanced Rectal Cancer
Start: 2025-07-01End: 2030-12-01Target: 90Updated: 2025-08-14
A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer
Not yet recruitingNCT07239466
Tao ZhangChemotherapy, Immunotherapy, Radiotherapy +1
Start: 2026-01-01End: 2027-06-01Target: 48Updated: 2025-11-20
Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)
Not yet recruitingNCT07243938
Tao ZhangLocally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma, Locally Advanced Rectal Cancer (LARC), Metastatic Colorectal Cancer (mCRC) +1
Start: 2026-01-15End: 2031-06-01Target: 70Updated: 2025-11-24

Phase 3

Unknown Phase

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