TME surgery
Sponsors
UNICANCER, Zhongnan Hospital, Ruijin Hospital, Kyungpook National University Hospital, JIN JING
Conditions
Cancer of the RectumChemotherapyImmunotherapyLocally AdvancedLocally Advanced Gastric/Gastroesophageal Junction AdenocarcinomaLocally Advanced Rectal CancerLocally Advanced Rectal Cancer (LARC)Metastatic Colorectal Cancer (mCRC)
Phase 2
SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer
RecruitingNCT05576480
Start: 2023-02-06End: 2026-12-31Target: 55Updated: 2025-08-28
Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
Active, not recruitingNCT05673772
Start: 2020-10-23End: 2031-12-28Target: 364Updated: 2026-02-12
Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC(AK104-IIT-13)
Not yet recruitingNCT05794750
Start: 2023-04-24End: 2027-04-24Target: 50Updated: 2023-04-06
Node-sparing Radiotherapy Combined with Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer
RecruitingNCT06204094
Start: 2024-02-05End: 2028-09-01Target: 37Updated: 2025-01-07
Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer
CompletedNCT06493240
Start: 2023-01-01End: 2025-04-01Updated: 2025-11-25
Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer
RecruitingNCT06802666
Start: 2024-10-16End: 2027-12-30Target: 45Updated: 2025-01-31
Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Field I)
RecruitingNCT07057089
Start: 2025-07-01End: 2030-12-01Target: 90Updated: 2025-08-14
A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed by Immunotherapy Combined With CAPEOX Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer
Not yet recruitingNCT07239466
Start: 2026-01-01End: 2027-06-01Target: 48Updated: 2025-11-20
Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)
Not yet recruitingNCT07243938
Start: 2026-01-15End: 2031-06-01Target: 70Updated: 2025-11-24
Phase 3
Efficacy of Neoadjuvant Folfirinox Regimen in Patients With Resectable Locally Advanced Rectal Cancer
CompletedNCT01804790
Start: 2012-01-31End: 2023-07-01Updated: 2025-06-12
A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in High-Risk Locally Advanced Rectal Cancer
Not yet recruitingNCT07113275
Start: 2026-02-11End: 2028-12-31Target: 435Updated: 2026-02-12