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TME

PROCEDURE10 trials

Sponsors

Johannes Gutenberg University Mainz, Harbin Medical University, West China Hospital, Case Comprehensive Cancer Center, The First Affiliated Hospital with Nanjing Medical University

Conditions

ChemoradiotherapyHigh Risk FactorsLocal Advanced Rectal CancerLocally Advanced Rectal CancerRectal CancerRectum CancerTotal Neoadjuvant Treatment

Phase 2

A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer
Active, not recruitingNCT04543695
Cancer Institute and Hospital, Chinese Academy of Medical SciencesRectal Cancer
Start: 2020-08-15End: 2025-06-01Target: 255Updated: 2024-03-26
A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk
NCT04664504
Jing Jin, M.D.Rectal Cancer
Start: 2020-12-01End: 2025-12-01Target: 150Updated: 2021-06-08
Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29
Active, not recruitingNCT05253846
Gruppo Oncologico del Nord-OvestLocally Advanced Rectal Cancer
Start: 2022-01-25End: 2028-10-30Target: 63Updated: 2026-07-24
Neoadjuvant Therapy for Locally Advanced Rectal Cancer With Fruquintinib, Toripalimab and SRT
NCT05763927
West China HospitalRectal Cancer
Start: 2022-09-01End: 2025-04-01Target: 44Updated: 2023-03-10

Phase 3

Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors
NCT03177382
West China HospitalChemoradiotherapy, High Risk Factors, Local Advanced Rectal Cancer +1
Start: 2017-06-15End: 2023-05-30Target: 458Updated: 2018-05-08

Phase 4

Total Neoadjuvant Therapy in Rectal Cancer Treatment
NCT04747951
State Scientific Centre of Coloproctology, Russian FederationRectal Cancer
Start: 2020-10-30End: 2023-11-01Target: 280Updated: 2021-02-15

Unknown Phase

Intraoperative Monitoring of the Pelvic Autonomic Nerves
CompletedNCT01585727
Johannes Gutenberg University MainzRectal Cancer
Start: 2012-06-30End: 2018-12-31Updated: 2019-02-27
Clinical Effect of Neoadjuvant Hierarchical Treatment Based on Chemotherapy
NCT03071198
Harbin Medical UniversityRectum Cancer
Start: 2017-03-01End: 2021-09-30Target: 1Updated: 2017-03-07
Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
Active, not recruitingNCT03283540
Case Comprehensive Cancer CenterRectal Cancer
Start: 2017-09-25End: 2025-08-31Updated: 2025-08-17
Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer
RecruitingNCT04098471
The First Affiliated Hospital with Nanjing Medical UniversityRectal Cancer
Start: 2021-10-01End: 2030-06-01Target: 168Updated: 2026-07-28

Related Papers

Total Neoadjuvant Therapy With Long-Course Radiotherapy Versus Chemoradiotherapy in High-Risk Locally Advanced Rectal Cancer (TNTCRT): A Multicenter, Randomized, Phase III Trial.
2026-07-23
Phase II study of short-course radiotherapy (SCRT) followed by consolidation chemotherapy with FOLFOXIRI as total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC) patients (pts): The ShorTrip study.
Journal of Clinical Oncology2025-05-28
Total neoadjuvant treatment with long-course radiotherapy versus concurrent chemoradiotherapy in local advanced rectal cancer with high risk factors (TNTCRT): A multicenter, randomized, open-label, phase 3 trial.
Journal of Clinical Oncology2024-06-0511 citations
Effectiveness of the total neo-adjuvant therapy in rectal cancer treatment. Results of the randomized trial
Koloproktologia2024-02-271 citations
Results of a prospective phase II study of total neoadjuvant therapy for locally advanced rectal cancer.
Journal of Clinical Oncology2024-01-20
Safety of the total neo-adjuvant therapy in rectal cancer treatment. Preliminary results of the randomized trial
Koloproktologia2022-09-151 citations
Total Mesorectal Excision vs. Transanal Endoscopic Microsurgery Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer: A Multicenter Randomized Trial
Frontiers in Surgery2022-02-013 citations
Continuous intraoperative monitoring of pelvic autonomic nerves during TME to prevent urogenital and anorectal dysfunction in rectal cancer patients (NEUROS): a randomized controlled trial
BMC Cancer2016-05-2128 citations