Tissue Plasminogen Activator (Alteplase)

DRUG3 trials

Sponsors

Neuroscience Trials Australia, Second Affiliated Hospital, School of Medicine, Zhejiang University

Conditions

StrokeStroke, Acute Ischemic

Phase 3

Extending the Time for Thrombolysis in Emergency Neurological Deficits

CompletedNCT00887328

Neuroscience Trials AustraliaStroke

Start: 2010-06-30End: 2018-08-27Updated: 2018-08-31

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

CompletedNCT01580839

Neuroscience Trials AustraliaStroke

Start: 2012-12-06End: 2018-08-22Updated: 2018-08-31

EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs

CompletedNCT05429476

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityStroke, Acute Ischemic

Start: 2022-08-17End: 2024-08-15Updated: 2024-12-18

Related Papers

Network‐level disconnectivity tracks poststroke depressive symptom improvement

Psychiatry and Clinical Neurosciences2026-05-14

Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours

New England Journal of Medicine2025-04-0329 citations

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores

Neural Plasticity2019-07-2813 citations

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

New England Journal of Medicine2019-05-08963 citations

Statistical Analysis Plan for EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND) trial

International Journal of Stroke2018-12-077 citations

Increased work and social engagement is associated with increased stroke specific quality of life in stroke survivors at 3 months and 12 months post-stroke: a longitudinal study of an Australian stroke cohort

Topics in Stroke Rehabilitation2017-04-2450 citations