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Tirofiban Hydrochloride

DRUG6 trials

Sponsors

The First Affiliated Hospital of Zhengzhou University, Capital Medical University, University of Iowa, Second Affiliated Hospital of Guangxi Medical University

Conditions

Acute Ischemic StrokeAcute StrokeCerebral InfarctionElective Percutaneous Coronary InterventionIschemic StrokeIschemic Stroke, AcutePrimary Percutaneous Coronary InterventionST Segment Elevation Myocardial Infarction

Phase 1

Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke
WithdrawnNCT04818944
University of IowaAcute Ischemic Stroke, Ischemic Stroke
Start: 2023-03-01End: 2025-09-01Updated: 2022-09-21

Phase 2

Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke
NCT04491695
Capital Medical UniversityAcute Stroke
Start: 2020-09-12End: 2023-03-31Target: 420Updated: 2022-07-19
Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke
Not yet recruitingNCT06587347
Capital Medical UniversityAcute Stroke, Cerebral Infarction, Ischemic Stroke, Acute
Start: 2024-11-20End: 2026-06-30Target: 302Updated: 2024-10-29

Phase 3

Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke
RecruitingNCT05604638
Second Affiliated Hospital of Guangxi Medical UniversityAcute Ischemic Stroke
Start: 2024-04-24End: 2026-03-31Target: 348Updated: 2025-12-24

Unknown Phase

Prevention of Coronary Slow Flow or No-Reflow During PPCI in Patients With Acute STEMI
NCT03406819
The First Affiliated Hospital of Zhengzhou UniversityPrimary Percutaneous Coronary Intervention, ST Segment Elevation Myocardial Infarction
Start: 2018-01-07End: 2019-12-31Target: 1000Updated: 2018-01-23
Prevention of Coronary Slow Flow or No-Reflow During EPCI in Patients With Acute STEMI
NCT03406832
The First Affiliated Hospital of Zhengzhou UniversityElective Percutaneous Coronary Intervention, ST Segment Elevation Myocardial Infarction
Start: 2018-01-08End: 2019-12-31Target: 1000Updated: 2019-06-07

Related Papers

Impact of Prestroke Antiplatelet Therapy on the Efficacy of Intravenous Tirofiban at Preventing Early Neurological Deterioration: A Prespecified Subgroup Analysis of the TREND Trial.
2026-01-20
Effects of tirofiban in preventing neurological deterioration in acute ischemic stroke with intracranial artery stenosis: A post hoc analysis of the TREND Trial
European Stroke Journal2025-02-143 citations
Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke
JAMA Neurology2024-04-2239 citations
Safety and efficacy of tirofiban in preventing neurological deterioration in acute ischemic stroke (TREND): Protocol for an investigator-initiated, multicenter, prospective, randomized, open-label, masked endpoint trial
Brain Circulation2024-04-018 citations