tirapazamine

DRUG18 trials

Sponsors

Stanford University, National Cancer Institute (NCI), SWOG Cancer Research Network, City of Hope Medical Center, Sanofi

Conditions

Alveolar Childhood RhabdomyosarcomaCarcinoma, HepatocellularCervical AdenocarcinomaCervical Adenosquamous Cell CarcinomaCervical CancerCervical Squamous Cell CarcinomaEmbryonal Childhood RhabdomyosarcomaEmbryonal-botryoid Childhood Rhabdomyosarcoma

Phase 1

Chemotherapy, Tirapazamine, and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer

CompletedNCT00033410

California Cancer ConsortiumLung Cancer

Start: 2002-03-31Target: 30Updated: 2009-02-09

Tirapazamine, Carboplatin, and Paclitaxel in Treating Patients With Advanced Malignant Solid Tumors

CompletedNCT00005078

City of Hope Medical CenterUnspecified Adult Solid Tumor, Protocol Specific

Start: 2000-03-31End: 2012-07-31Updated: 2015-06-08

S0004: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-stage Small Cell Lung Cancer

CompletedNCT00006487

SWOG Cancer Research NetworkLung Cancer

Start: 2000-10-31End: 2004-07-31Updated: 2012-10-04

Tirapazamine Plus Cyclophosphamide in Treating Children With Refractory Solid Tumors

CompletedNCT00003288

National Cancer Institute (NCI)Unspecified Childhood Solid Tumor, Protocol Specific

Start: 1998-08-31Updated: 2013-02-05

Tirapazamine, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

CompletedNCT00098995

Peter MacCallum Cancer Centre, AustraliaCervical Cancer

Start: 2004-12-31End: 2010-01-31Target: 22Updated: 2013-06-26

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

RecruitingNCT02174549

Teclison Ltd.Gastrointestinal Cancer Metastatic, Hepatocellular Carcinoma, Neuroendocrine Tumors

Start: 2014-09-30End: 2025-12-31Target: 25Updated: 2024-11-22

Evaluate the Effect of Tirazamine on Primary Liver Cancer.

TerminatedNCT06848556

Zhejiang Raygene Pharmaceuticals Co., LtdHepato Cellular Carcinoma (HCC)

Start: 2021-05-14End: 2023-11-20Updated: 2025-02-27

Phase 2

Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma

CompletedNCT00025363

National Cancer Institute (NCI)Alveolar Childhood Rhabdomyosarcoma, Embryonal-botryoid Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma +2

Start: 2001-11-30Updated: 2013-01-17

Tirapazamine Combined With Chemo and RT in Limited-Stage Small Cell Lung Cancer

CompletedNCT00066742

National Cancer Institute (NCI)Limited Stage Small Cell Lung Cancer

Start: 2003-09-30End: 2009-08-31Updated: 2014-05-15

Tirapazamine Plus Cisplatin in Treating Patients With Persistent or Recurrent Ovarian Epithelial or Primary Peritoneal Cancer

CompletedNCT00020696

Gynecologic Oncology GroupOvarian Cancer, Primary Peritoneal Cavity Cancer

Start: 2001-06-30Updated: 2012-01-10

Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer

CompletedNCT00002774

Stanford UniversitySquamous Neck Carcinoma of the Head and Neck Cancer (SCCHN)

Start: 1996-06-30End: 2005-06-30Updated: 2014-06-20

S9717 Tirapazamine Plus Cisplatin in Treating Patients With Metastatic, Recurrent, or Refractory Cervical Cancer

CompletedNCT00003369

SWOG Cancer Research NetworkCervical Cancer

Start: 1998-08-31End: 2004-07-31Updated: 2012-06-14

TATE Versus TACE in Intermediate Stage HCC

TerminatedNCT03145558

Teclison Ltd.Carcinoma, Hepatocellular

Start: 2017-12-05End: 2024-06-30Updated: 2024-11-22

A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer.

RecruitingNCT06844357

Zhejiang Raygene Pharmaceuticals Co., LtdHCC

Start: 2025-03-27End: 2029-04-01Target: 300Updated: 2025-04-06

Phase 3

Combination Chemotherapy With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

CompletedNCT00006484

SWOG Cancer Research NetworkLung Cancer

Start: 2000-11-30End: 2006-04-30Updated: 2013-06-24

Cisplatin Plus Vinorelbine With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

CompletedNCT00017459

SanofiLung Cancer

Start: 2000-07-31End: 2004-02-29Updated: 2013-08-02

TRACE: Tirapazamine-Radiation And Cisplatin Evaluation

CompletedNCT00174837

SanofiHead and Neck Squamous Cell Carcinoma

Start: 2005-04-30End: 2008-01-31Updated: 2016-05-26

Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer

TerminatedNCT00262821

National Cancer Institute (NCI)Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, Cervical Squamous Cell Carcinoma +5

Start: 2006-02-28End: 2010-08-31Updated: 2019-07-23