Tiragolumab placebo
Sponsors
F. Hoffmann-La Roche AG, Genentech Inc.
Conditions
Non-small cell lung cancer (NSCLC)Non-squamous non-small cell lung cancer (NSCLC)Squamous cell carcinoma of the head and neck (SCCHN)Unresectable Esophageal Squamous Cell Carcinoma
Phase 2
A Phase II, Randomized, Blinded, Placebo-Controlled Study of Tiragolumab, an Anti- TIGIT Antibody, in Combination with Atezolizumab in Chemotherapy-Naive Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer
CompletedCTIS2023-508083-30-00
Start: 2018-07-19End: 2025-07-08Target: 47Updated: 2025-05-26
A Phase II/III, Randomized, Double-Blind, Placebo-Controlled Study of Tiragolumab in combination with Atezolizumab plus Pemetrexed and Carboplatin/Cisplatin versus Pembrolizumab plus Pemetrexed and Carboplatin/Cisplatin in Patients with previously Untreated Advanced Non-Squamous Non-Small-Cell Lung Cancer
CompletedCTIS2022-502031-20-00
Start: 2020-12-17End: 2025-08-22Target: 149Updated: 2025-09-27
A Phase II, Randomized, Double-Blind Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Patients with Recurrent/Metastatic PD-L1-Positive Squamous Cell Carcinoma of the Head and Neck
CompletedCTIS2023-509449-10-00
Start: 2021-03-16End: 2025-08-27Target: 72Updated: 2025-08-04