TIOGUANINE

DRUG8 trials

Sponsors

Karolinska University Hospital, Universitaetsklinikum Muenster AöR, Universitaetsklinikum Schleswig-Holstein, Universita Degli Studi Di Milano Bicocca, Medical University Of Silesia Katowice Poland

Conditions

Acute Lymphoblastic LeukaemiaAcute lymphoblastic leukemiaLymphoblastic lymphomaOncologyacute lymphoblastic leukemia in children and adolescents

Phase 1

TEMPLE - Thiopurine Enhanced Mutations for PD-1/Ligand-1 Efficacy

CompletedCTIS2024-517307-37-00

RigshospitaletOncology

Start: 2022-09-01End: 2024-12-20Target: 39Updated: 2024-11-11

Phase 2

ALLTogether1 - A Treatment Study Protocol of the ALLTogether Consortium for Children and Young Adults (0-45 Years of Age) with Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL)

RecruitingCTIS2022-501050-11-01

Karolinska University HospitalAcute Lymphoblastic Leukaemia

Start: 2020-07-13Target: 5943Updated: 2025-12-17

Ruxolitinib for childhood ALL in Poland (Rux-cALL-Pol 2020 trial) - Single-arm interventional study with ruxolitinib and AIEOP-BFM 2017 Poland or AIEOP-BFM 2017 standard of care chemotherapy in children with acute lymphoblastic leukemia and confirmed activation of JAK/STAT pathway.

Not yet recruitingCTIS2024-518316-39-00

Medical University Of LodzAcute lymphoblastic leukemia

Target: 25Updated: 2025-04-04

Phase 3

LBL 2018 - International cooperative treatment protocol for children and adolescents with lymphoblastic lymphoma

RecruitingCTIS2023-508101-24-00

Universitaetsklinikum Muenster AöRLymphoblastic lymphoma

Start: 2019-08-01Target: 544Updated: 2026-01-23

AIEOP-BFM ALL 2017 - International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia

Active, not recruitingCTIS2023-509856-32-00

Universitaetsklinikum Schleswig-Holsteinacute lymphoblastic leukemia in children and adolescents

Start: 2018-07-15Target: 4250Updated: 2025-08-19

International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones

Active, not recruitingCTIS2024-515499-12-00

Universita Degli Studi Di Milano BicoccaAcute lymphoblastic leukemia

Start: 2017-10-02Target: 306Updated: 2024-11-12

Collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia. A randomized phase III study conducted in agreement with the AIEOP-BFM study group.

Active, not recruitingCTIS2024-517253-27-00

Medical University Of Silesia Katowice PolandAcute lymphoblastic leukemia

Start: 2021-07-01Target: 874Updated: 2024-10-28

AIEOP-BFM ALL 2025 - International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia

Not yet recruitingCTIS2025-522190-11-01

Universitaetsklinikum Schleswig-Holstein AöRacute lymphoblastic leukemia in children and adolescents

Target: 2250Updated: 2026-07-09

Related Papers

DNA-incorporated thioguanine to detect potential non-adherence to maintenance therapy in acute lymphoblastic leukemia.

2025-07-161 citations