Tight blood pressure management

PROCEDURE4 trials

Sponsors

Miodrag Filipovic, Prof. Dr. med., The University of Texas Health Science Center, Houston

Conditions

Acute Coronary SyndromeAcute Kidney InjuryBlood PressureCoronary OcclusionDeathHeart FailureHypotensionMajor Surgery

Phase 4

The GUARDIAN Trial - Vasopressor Sub-Study

Enrolling by invitationNCT04934748

The University of Texas Health Science Center, HoustonBlood Pressure

Start: 2021-07-25End: 2027-04-25Target: 6254Updated: 2025-08-29

The GUARDIAN Trial - Induction Agent Sub-Study

Enrolling by invitationNCT04934683

The University of Texas Health Science Center, HoustonMajor Surgery

Start: 2021-07-25End: 2027-04-25Target: 6254Updated: 2025-08-29

Unknown Phase

Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery

CompletedNCT02533128

Miodrag Filipovic, Prof. Dr. med.Acute Coronary Syndrome, Acute Kidney Injury, Coronary Occlusion +6

Start: 2015-10-14End: 2020-04-17Updated: 2020-07-15

The GUARDIAN Trial

RecruitingNCT04884802

The University of Texas Health Science Center, HoustonBlood Pressure

Start: 2021-07-25End: 2027-04-25Target: 6254Updated: 2025-08-29

Related Papers

Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery

Journal of the American College of Cardiology2021-10-25115 citations

Effect of Hyperoxia on Myocardial Oxygenation and Function in Patients With Stable Multivessel Coronary Artery Disease.

2020-02-2226 citations