therapeutic tumor infiltrating lymphocytes

BIOLOGICAL18 trials

Sponsors

St. Luke's Medical Center, University of Colorado, Denver, Hoag Memorial Hospital Presbyterian, Fred Hutchinson Cancer Center, National Cancer Institute (NCI)

Conditions

Brain and Central Nervous System TumorsBreast CancerCervical CancerColorectal CancerInfectionKidney CancerLocally Advanced Cervical CarcinomaLocally Advanced Colorectal Carcinoma

Phase 1

Chemotherapy and Peripheral Stem Cell Transplantation Followed By Immunotherapy in Treating Patients With Multiple Myeloma

CompletedNCT00046852

University of Maryland, BaltimoreInfection, Multiple Myeloma and Plasma Cell Neoplasm

Start: 2001-12-31End: 2008-02-29Updated: 2019-11-04

Biological Therapy in Treating Patients With Metastatic Melanoma

CompletedNCT00002786

Fred Hutchinson Cancer CenterMelanoma (Skin)

Start: 1995-10-31End: 2006-03-31Target: 20Updated: 2010-05-10

Biological Therapy in Treating Patients With Metastatic Melanoma

CompletedNCT00045149

Fred Hutchinson Cancer CenterMelanoma (Skin)

Start: 2002-10-31End: 2005-06-30Updated: 2010-05-07

Cyclophosphamide and Fludarabine Followed By Interleukin-2 Gene-Modified Tumor Infiltrating Lymphocytes in Treating Patients With Metastatic Melanoma

CompletedNCT00062036

National Institutes of Health Clinical Center (CC)Melanoma (Skin)

Start: 2003-06-30End: 2008-09-30Target: 33Updated: 2017-07-02

Vaccine Therapy in Treating Patients With Stage IV Melanoma

CompletedNCT00003665

National Cancer Institute (NCI)Melanoma (Skin)

Start: 1999-04-30End: 2002-11-30Updated: 2013-02-28

Interleukin-2 Plus Activated White Blood Cells in Treating Patients With Cancer That Has Not Responded to Chemotherapy or Radiation Therapy

CompletedNCT00019357

National Cancer Institute (NCI)Unspecified Adult Solid Tumor, Protocol Specific

Start: 1998-06-30Updated: 2015-04-29

Gene-Modified White Blood Cells Followed By Interleukin-2 and Vaccine Therapy in Treating Patients With Metastatic Melanoma

CompletedNCT00085462

National Institutes of Health Clinical Center (CC)Melanoma (Skin)

Start: 2004-05-31End: 2008-09-30Target: 61Updated: 2012-06-22

Cytotoxic T Cells and Interleukin-2 in Treating Adult Patients With Recurrent Brain Tumors

CompletedNCT00002572

University of Colorado, DenverBrain and Central Nervous System Tumors

Start: 1994-11-30End: 1999-12-31Target: 10Updated: 2013-05-30

Cyclophosphamide and Fludarabine Followed by Vaccine Therapy, Gene-Modified White Blood Cell Infusions, and Aldesleukin in Treating Patients With Metastatic Melanoma

CompletedNCT00091104

National Institutes of Health Clinical Center (CC)Melanoma (Skin)

Start: 2004-07-31End: 2010-10-31Target: 136Updated: 2012-03-15

Cellular Adoptive Immunotherapy in Treating a Patient Who Has Undergone a Donor Stem Cell Transplant for Breast Cancer That Has Spread to the Lung

CompletedNCT00301730

National Cancer Institute (NCI)Breast Cancer, Metastatic Cancer

Start: 2005-10-31Target: 1Updated: 2015-04-28

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

WithdrawnNCT06626256

City of Hope Medical CenterLocally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma, Locally Advanced Malignant Solid Neoplasm +24

Start: 2025-12-05End: 2027-10-30Updated: 2025-12-24

Phase 2

Vaccine Therapy Followed by Biological Therapy in Treating Patients With Stage III or Stage IV Melanoma

TerminatedNCT00006113

University of Southern CaliforniaMelanoma (Skin)

Start: 1999-06-30End: 2006-04-30Updated: 2014-05-22

Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer

CompletedNCT00019084

National Cancer Institute (NCI)Breast Cancer, Cervical Cancer, Colorectal Cancer +3

Start: 1996-02-29End: 2003-05-31Updated: 2013-06-20

Biological Therapy in Treating Patients With Metastatic Cancer

CompletedNCT00002733

Hoag Memorial Hospital PresbyterianKidney Cancer, Melanoma (Skin), Unspecified Adult Solid Tumor, Protocol Specific

Start: 1996-01-31End: 2000-01-31Target: 30Updated: 2011-05-11

Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma

CompletedNCT00002535

St. Luke's Medical CenterMelanoma (Skin)

Start: 1993-07-31End: 2004-07-31Updated: 2013-06-26

Cyclophosphamide, Fludarabine, and Total-Body Irradiation Followed By Cellular Adoptive Immunotherapy, Autologous Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Metastatic Melanoma

CompletedNCT00096382

National Institutes of Health Clinical Center (CC)Melanoma (Skin)

Start: 2004-09-30End: 2009-01-31Updated: 2015-10-28

Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma

CompletedNCT01807182

Fred Hutchinson Cancer CenterMetastatic Melanoma, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7 +3

Start: 2013-08-20End: 2021-08-26Updated: 2022-11-10

Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma

CompletedNCT02500576

M.D. Anderson Cancer CenterMetastatic Melanoma, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7 +1

Start: 2015-08-07End: 2022-10-12Updated: 2025-01-15

Related Papers

Lymphodepletion (LD), tumor-infiltrating lymphocytes (TIL) and high (HD-IL2) versus low-dose (LD-IL2) IL-2 followed by pembrolizumab (pembro) in patients (pts) with metastatic melanoma (MM).

Journal of Clinical Oncology2019-05-203 citations

Clinical Predictors of T Cell Fitness for CAR T Cell Manufacturing and Efficacy in Multiple Myeloma

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Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.

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