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Tetravalent Dengue Vaccine (TDV)

BIOLOGICAL4 trials

Sponsors

Takeda

Conditions

DengueDengue FeverHealthy Volunteers

Phase 3

Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children
CompletedNCT02747927
TakedaHealthy Volunteers
Start: 2016-04-26End: 2024-06-28Updated: 2025-11-19
Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s)
CompletedNCT03341637
TakedaDengue
Start: 2017-12-14End: 2019-01-26Updated: 2019-08-15
Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) at the End of Shelf Life in Healthy Adults
CompletedNCT03771963
TakedaDengue Fever
Start: 2019-03-28End: 2020-03-13Updated: 2021-06-07
A Study on a New Tetravalent Dengue Vaccine (TDV) Formulation in Healthy Adults
Active, not recruitingNCT07047521
TakedaDengue Fever
Start: 2025-11-07End: 2026-12-22Updated: 2026-07-17

Related Papers

Beyond neutralization: A comprehensive framework for evaluating humoral immunity induced by a live-attenuated tetravalent dengue vaccine.
2026-07-21
Burden of dengue in children in eight endemic countries in Asia and Latin America: a secondary analysis of the DEN-301 trial
Nature Health2026-07-08
Operational challenges and lessons learned from conducting febrile surveillance in a long-term randomized dengue vaccine trial in Latin America and Asia-Pacific.
2025-03-20
Pregnancy outcomes following unintentional exposure to TAK-003, a live-attenuated tetravalent dengue vaccine
Expert Review of Vaccines2025-03-184 citations
Estimated Efficacy of TAK-003 Against Asymptomatic Dengue Infection in Children and Adolescents Participating in the DEN-301 Trial in Asia Pacific and Latin America
The Journal of Infectious Diseases2025-03-184 citations
Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward
International Journal of Infectious Diseases2025-02-28
Long term T cell response and safety of a tetravalent dengue vaccine in healthy children.
2024-10-1710 citations
Role of the dengue vaccine TAK-003 in an outbreak response: Modeling the Sri Lanka experience
PLoS neglected tropical diseases2024-08-224 citations
Immunogenicity, Safety, and Efficacy of a Tetravalent Dengue Vaccine in Children and Adolescents: An Analysis by Age Group
Clinical Infectious Diseases2024-07-1211 citations
Efficacy and Safety of a Tetravalent Dengue Vaccine (TAK-003) in Children With Prior Japanese Encephalitis or Yellow Fever Vaccination
The Journal of Infectious Diseases2024-04-2614 citations
Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4·5-year results from a phase 3, randomised, double-blind, placebo-controlled trial.
2024-02-01118 citations
An open-label, Phase 3 trial of TAK-003, a live attenuated dengue tetravalent vaccine, in healthy US adults: immunogenicity and safety when administered during the second half of a 24-month shelf-life
Human Vaccines & Immunotherapeutics2023-08-0132 citations
Effect of the Tetravalent Dengue Vaccine TAK-003 on Sequential Episodes of Symptomatic Dengue
American Journal of Tropical Medicine and Hygiene2023-03-0624 citations
Immunogenicity and safety of a tetravalent dengue vaccine in dengue-naïve adolescents in Mexico City
Revista Panamericana de Salud Pública2021-06-1120 citations
Efficacy of a Dengue Vaccine Candidate (TAK-003) in Healthy Children and Adolescents 2 Years after Vaccination
The Journal of Infectious Diseases2020-12-1099 citations
Long-term Safety and Immunogenicity of a Tetravalent Dengue Vaccine Candidate in Children and Adults: A Randomized, Placebo-Controlled, Phase 2 Study
The Journal of Infectious Diseases2020-07-1114 citations
Efficacy of a tetravalent dengue vaccine in healthy children aged 4-16 years: a randomised, placebo-controlled, phase 3 trial.
2020-03-17171 citations
Immunogenicity and safety of lyophilized and liquid dengue tetravalent vaccine candidate formulations in healthy adults: a randomized, phase 2 clinical trial
Human Vaccines & Immunotherapeutics2020-03-0229 citations
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents
New England Journal of Medicine2019-11-06353 citations
Phase I Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults from Puerto Rico
American Journal of Tropical Medicine and Hygiene2018-03-0643 citations