Tetrahydrouridine (THU)

DRUG3 trials

Sponsors

City of Hope Medical Center, National Cancer Institute (NCI)

Conditions

Carcinoma, EsophagealCarcinoma, Non-Small-Cell LungLung CancerMalignant Pleural MesotheliomasMelanomaNeoplasm MetastasisNeoplasmsNeoplasms, Germ Cell and Embryonal

Phase 1

5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer

CompletedNCT00359606

City of Hope Medical CenterNeoplasms

Start: 1999-04-30End: 2012-06-30Updated: 2015-05-06

Adjuvant Oral Decitabine and Tetrahydrouridine With or Without Celecoxib in People Undergoing Pulmonary Metastasectomy

WithdrawnNCT02839694

National Cancer Institute (NCI)Melanoma, Neoplasm Metastasis, Neoplasms, Germ Cell and Embryonal +1

Start: 2016-07-07End: 2017-04-26Updated: 2018-07-05

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

TerminatedNCT03233724

National Cancer Institute (NCI)Carcinoma, Esophageal, Carcinoma, Non-Small-Cell Lung, Lung Cancer +2

Start: 2018-04-11End: 2021-10-26Updated: 2023-05-31