Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)

DRUG7 trials

Sponsors

University of Alberta, Memorial Hermann Health System, Second Affiliated Hospital, School of Medicine, Zhejiang University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Xuanwu Hospital, Beijing

Conditions

Acute Ischemic StrokeBrain IschemiaCerebral InfarctionLarge Vessel OcclusionStrokeStroke IschemicTenecteplaseTransportation of Patients

Phase 1

Safety Of A Second Dose Of Tenecteplase In Selected Acute Ischemic Stroke Patients Not Responding To The First Dose

Not yet recruitingNCT06801054

Memorial Hermann Health SystemAcute Ischemic Stroke

Start: 2025-07-01End: 2026-09-30Target: 20Updated: 2025-06-05

Phase 2

Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke

CompletedNCT02101606

University of AlbertaBrain Ischemia, Cerebral Infarction, Stroke

Start: 2009-10-31End: 2017-11-30Updated: 2018-04-06

Phase 3

Tenecteplase in ReperfUsion Therapy for Posterior Circulation Stroke With Extended Time Window: the TRUST Trial

Not yet recruitingNCT07073469

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityStroke Ischemic

Start: 2025-09-01End: 2027-11-01Target: 330Updated: 2025-08-15

Tenecteplase for Intravenous Stroke Thrombolysis in Recent DOAC Users

RecruitingNCT07092709

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityAcute Ischemic Stroke

Start: 2025-08-14End: 2028-12-31Target: 912Updated: 2025-12-16

Tenecteplase Before Interhospital Transfer for EVT in Acute Anterior Circulation LVO at 4.5-24 Hours

RecruitingNCT07253181

Xuanwu Hospital, BeijingAcute Ischemic Stroke, Large Vessel Occlusion, Transportation of Patients

Start: 2026-01-06End: 2028-03-30Target: 572Updated: 2026-08-19

Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging

Not yet recruitingNCT07475949

First Affiliated Hospital of Guangxi Medical UniversityAcute Ischemic Stroke, Tenecteplase

Start: 2026-09-01End: 2028-12-01Target: 352Updated: 2026-08-31

Unknown Phase

Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke

RecruitingNCT07475936

First Affiliated Hospital of Guangxi Medical UniversityAcute Ischemic Stroke, Tenecteplase

Start: 2026-03-22End: 2027-12-01Target: 392Updated: 2026-08-31