Telisotuzumab Vedotin
Sponsors
Abbvie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, AbbVie, Jonsson Comprehensive Cancer Center
Conditions
Advanced Solid Tumors CancerLung Non-Small Cell CarcinomaNon Small Cell Lung CancerNon-Small Cell Lung CancerNon-Small Cell Lung Cancer (NSCLC)Non-small Cell Lung CancerPreviously Untreated MET Amplified Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancerc-Met overexpressing EGFR wildtype non-squamous non-small cell lung cancer
Phase 1
Phase 2
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
Active, not recruitingNCT03539536
Start: 2018-10-10End: 2026-08-31Updated: 2025-11-05
A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
TerminatedNCT05513703
Start: 2022-11-21End: 2024-10-28Updated: 2025-10-24
Phase 2, Open-Label Study in Subjects with Previously Untreated MET Amplified Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
CompletedCTIS2022-500608-23-00
Start: 2023-04-06End: 2024-10-28Target: 20Updated: 2024-08-29
Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects with Previously Treated c-Met+ Non-Small Cell Lung Cancer
Active, not recruitingCTIS2023-507902-15-00
Start: 2019-03-26Target: 67Updated: 2025-01-28
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
RecruitingNCT06568939
Start: 2025-01-20End: 2028-02-01Target: 150Updated: 2026-09-15
Telisotuzumab Vedotin and Osimertinib for the Treatment of Progressive, Incurable, Non Small Cell Lung Cancer
RecruitingNCT07323641
Start: 2026-02-19End: 2028-02-01Target: 60Updated: 2026-04-20
Phase 3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
RecruitingNCT04928846
Start: 2022-03-25End: 2029-02-01Target: 768Updated: 2026-09-16
Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met Protein
WithdrawnNCT06093503
Start: 2024-05-31End: 2028-04-11Updated: 2024-06-26
A Phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects with Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer
RecruitingCTIS2023-505749-14-00
Start: 2022-03-20Target: 222Updated: 2025-10-06
Unknown Phase
Related Papers
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