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Telisotuzumab Adizutecan

DRUG17 trials

Sponsors

AbbVie Deutschland GmbH & Co. KG, AbbVie

Conditions

Colorectal CancerEsophageal AdenocarcinomaGastric/Esophageal CancerGastroesophageal Junction AdenocarcinomaHead and Neck Squamous Cell CarcinomaHigh-Grade Serous Ovarian CancerLocally Advanced Unresectable or Metastatic Gastric AdenocarcinomaMetastatic Colorectal Cancer

Phase 1

Phase 2

A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
RecruitingNCT06628310
AbbVieEsophageal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma
Start: 2024-12-13End: 2030-10-01Target: 180Updated: 2026-03-30
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
RecruitingNCT06820463
AbbVieMetastatic Colorectal Cancer
Start: 2025-04-24End: 2028-04-01Target: 390Updated: 2026-04-03
A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
RecruitingNCT07005102
AbbVieNon-Squamous Non-Small Cell Lung Cancer
Start: 2025-08-03End: 2031-12-01Target: 854Updated: 2026-04-03
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
RecruitingNCT07023289
AbbVieColorectal Cancer
Start: 2025-08-07End: 2029-11-01Target: 140Updated: 2026-03-13
A Phase 2, Open-Label, Randomized, Master Protocol Study to Evaluate Safety and Efficacy of Multiple Treatment Combinations with Telisotuzumab Adizutecan in Subjects with Metastatic Colorectal Cancer (AndroMETa-CRC-533)
RecruitingCTIS2024-512981-33-00
AbbVie Deutschland GmbH & Co. KGMetastatic Colorectal Cancer
Start: 2025-07-09Target: 104Updated: 2025-11-25
A Phase 2, Randomized, Open-Label Study Comparing Telisotuzumab Adizutecan (ABBV-400) Monotherapy to the Current Standard of Care in Subjects with Post Adjuvant ctDNA Positive Colorectal Cancer and No Radiographic Evidence of Disease (NED)
RecruitingCTIS2024-518015-19-00
AbbVie Deutschland GmbH & Co. KGColorectal Cancer
Start: 2025-09-24Target: 24Updated: 2026-01-14
A Phase 2/3 Randomized Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab Adizutecan in Combination with Osimertinib as First-Line Treatment in Patients with Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
RecruitingCTIS2024-518586-10-00
AbbVie Deutschland GmbH & Co. KGNon-Squamous Non-Small Cell Lung Cancer
Start: 2025-09-18Target: 44Updated: 2025-11-24
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
RecruitingNCT07155187
AbbVieNon-Small Cell Lung Cancer
Start: 2025-12-10End: 2030-09-01Target: 430Updated: 2026-03-11
A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan
RecruitingNCT07196644
AbbVieSolid Tumors Harboring MET Amplification
Start: 2025-10-29End: 2030-12-01Target: 125Updated: 2026-03-11
Phase 2/3 Open Label Randomized Study of Telisotuzumab Adizutecan Compared to Standard of Care in Subjects with Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer After Progression on a Third-Generation EGFR TKI - AndroMETa-Lung-713
Not yet recruitingCTIS2025-521124-29-00
AbbVie Deutschland GmbH & Co. KGNon-Small Cell Lung Cancer
Target: 25Updated: 2026-02-10
A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma
Not yet recruitingNCT07490301
AbbVieMetastatic Pancreatic Ductal Adenocarcinoma, PDAC
Start: 2026-06-03End: 2031-06-01Target: 900Updated: 2026-03-24

Phase 3

Unknown Phase

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