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TEDOPI

DRUG8 trials

Sponsors

OSE Immunotherapeutics, Asso De Recherche Cancers Gynecologiques, Association Gercor, Fondazione Ricerca Traslazionale

Conditions

Metastatic Non Small Cell Lung CancerNSCLCNSCLC non-small cell lung cancerPart A: Patients with advanced solid tumors or lymphomas.Part B and C: Patients with HLA-A2 positive phenotype and metastatic Non Small Cell Lung Cancer.Patients with HLA-A2 positive phenotype and metastatic Non-Small Cell Lung Cancer.Platinum sensitive recurrent ovarian cancerlocally advanced or metastatic Pancreatic ductal adenocarcinoma

Phase 1

Phase 2

Efficacy of Tedopi Plus Docetaxel or Tedopi Plus Nivolumab as Second-line Therapy in Metastatic Non-small-cell Lung Cancer Progressing After First-line Chemo-immunotherapy (Combi-TED)
Active, not recruitingNCT04884282
Fondazione Ricerca TraslazionaleMetastatic Non Small Cell Lung Cancer
Start: 2021-10-12End: 2028-09-30Target: 105Updated: 2026-02-06
Randomized Phase II study comparing neo-epitope based vaccine OSE2101 (TEDOPI®) with or without anti-PD1 (Pembrolizumab) versus best supportive care as maintenance treatment in platinum-sensitive recurrent ovarian cancer patient with controlled disease after Platinum-based chemotherapy (TEDOVA Study)
Active, not recruitingCTIS2024-516096-32-00
Asso De Recherche Cancers GynecologiquesPlatinum sensitive recurrent ovarian cancer
Start: 2021-08-05Target: 180Updated: 2026-01-23
A randomized non-comparative phase II study of Maintenance therapy with OSE2101 plus FOLFIRI, or FOLFIRI after induction therapy with FOLFIRINOX in patients with locally advanced or metastatic Pancreatic ductal adenocarcinoma.
Not yet recruitingCTIS2024-518139-12-00
Association Gercorlocally advanced or metastatic Pancreatic ductal adenocarcinoma
Target: 106Updated: 2024-11-14
A multicenter, Phase II, open label, randomized trial evaluating the efficacy of Tedopi plus docetaxel or Tedopi plus nivolumab as second-line therapy in metastatic non-small-cell lung cancer progressing after first-line chemo-immunotherapy (Combi-TED)
RecruitingCTIS2024-518224-74-01
Fondazione Ricerca Traslazionalemetastatic non-small-cell lung cancer
Start: 2025-02-07Target: 105Updated: 2025-12-05
A Randomized phase II trial of Cemiplimab plus OSE2101 (TEDOPI®) as maintenance therapy in ctDNA positive NSCL. The Cemited study.
RecruitingCTIS2024-519262-42-00
Fondazione Ricerca TraslazionaleNSCLC non-small cell lung cancer
Start: 2025-07-15Target: 90Updated: 2025-08-13
A Randomized Phase II Trial of Cemiplimab Plus OSE2101 ( TEDOPI®) as Maintenance Therapy in ctDNA Positive NSCL. The Cemited Study.
RecruitingNCT07264673
Fondazione Ricerca TraslazionaleNSCLC
Start: 2025-04-17End: 2029-10-31Target: 160Updated: 2025-12-04

Phase 3

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