Tedizolid phosphate

DRUG5 trials

Conditions

Acute Bacterial Skin and Skin Structure InfectionsObesityPneumoniaSkin Diseases, Bacterialfirst suspected infection with Mycobacterium tuberculosis in the lungs

Phase 1

A Study to Evaluate the Effects of Tedizolid Phosphate on the Pharmacokinetics and Safety of Midazolam and Rosuvastatin (MK-1986-004)

CompletedNCT02477514

Merck Sharp & Dohme LLCSkin Diseases, Bacterial

Start: 2015-06-30End: 2015-08-31Updated: 2015-08-24

Phase 2

Evaluation of the early bactericidal activity of tedizolid and linezolide against Mycobacterium tuberculosis (TEDITUB)

RecruitingCTIS2024-512759-19-00

Assistance Publique Hopitaux De Parisfirst suspected infection with Mycobacterium tuberculosis in the lungs

Start: 2023-04-20Target: 60Updated: 2025-04-28

Phase 3

Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)

CompletedNCT02019420

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Pneumonia

Start: 2014-01-06End: 2018-06-22Updated: 2019-06-27

A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to Less Than 12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018)

CompletedNCT03176134

Merck Sharp & Dohme LLCAcute Bacterial Skin and Skin Structure Infections

Start: 2019-01-20End: 2023-07-06Updated: 2025-07-31

Phase 4

Single Dose PK of IV Tedizolid Phosphate in Morbidly Obese and Non-Obese Adults

CompletedNCT02342418

Amit.PaiObesity

Start: 2015-03-31End: 2015-12-31Updated: 2017-03-15

The Pediatric Infectious Disease Journal2025-04-143 citations

Efficacy and safety of tedizolid for the treatment of ventilated gram-positive hospital-acquired or ventilator-associated bacterial pneumonia in Japanese patients: Results from a subgroup analysis of a phase 3, randomized, double-blind study comparing tedizolid and linezolid

Journal of Infection and Chemotherapy2022-06-164 citations

A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia

Clinical Infectious Diseases2021-02-0554 citations

2841. A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate (TZD) and Linezolid (LZD) for Treatment of Ventilated Gram-Positive (G+) Nosocomial Pneumonia

Open Forum Infectious Diseases2019-10-012 citations

Tedizolid phosphate for the treatment of acute bacterial skin and skin-structure infections: an evidence-based review of its place in therapy.

2019-07-0513 citations

Pharmacokinetics of Tedizolid in Morbidly Obese and Covariate-Matched Nonobese Adults

Antimicrobial Agents and Chemotherapy2016-05-1722 citations