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Tecentriq 840 mg concentrate for solution for infusion

DRUG20 trials

Sponsors

Karolinska University Hospital, ETOP IBCSG Partners Foundation, Institut Curie, F. Hoffmann-La Roche AG, Universitaetsklinikum Essen AöR

Conditions

Advanced CancerCancerColorectal liver metastases (CRLM)Extensive-disease small cell lung cancer and high SLFN11-expressionHepatocellular carcinomaHigh-risk muscle-invasive bladder cancerInoperable locally advanced or metastatic TNBC patientsMalignant pleural mesothelioma

Phase 1

Phase 2

Molecular PD-L1 PET/CT Imaging with 89Zr-atezolizumab to Monitor Immune Responses in metastatic Triple Negative Breast Cancer
CompletedCTIS2022-500808-21-00
Karolinska University HospitalMetastatic triple negative breast cancer
Start: 2023-02-01End: 2024-12-23Target: 64Updated: 2022-12-05
"neoBREASTIM": A Phase 2 Study of Atezolizumab plus RP1 oncolytic immunotherapy in the NeoAdjuvant setting of Triple-Negative Breast Cancer (TNBC)
CompletedCTIS2022-502311-12-00
Institut CuriePatients with early-stage Triple Negative Breast Cancer
Start: 2024-04-05End: 2025-05-07Target: 51Updated: 2025-01-17
A Phase II, Single-Arm Study of Atezolizumab in Patients with Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer who have not Progressed after Platinum-Based Concurrent Chemoradiation
CompletedCTIS2023-503756-27-00
F. Hoffmann-La Roche AGNon-Small Cell Lung Cancer (NSCLC)
Start: 2022-03-31End: 2025-11-21Target: 13Updated: 2025-10-23
ETOP 23-22 RAISE: A single-arm phase II study of the addition of niraparib to anti-PD-L1 antibody maintenance in patients with SLFN11-positive, extensive-disease small cell lung cancer.
RecruitingCTIS2022-502092-33-00
ETOP IBCSG Partners FoundationExtensive-disease small cell lung cancer and high SLFN11-expression
Start: 2024-05-31Target: 35Updated: 2025-12-10
A PHASE II, OPEN LABEL, RANDOMIZED, NON-COMPARATIVE COHORTS STUDY OF ADJUVANT ATEZOLIZUMAB OR ATEZOLIZUMAB PLUS TIRAGOLUMAB IN SOLID TUMORS WITH RESECTABLE DISEASE WITH INTERMEDIATE-HIGH RISK OF RECURRENCE AND HIGH TUMOR MUTATIONAL BURDEN (TMB-H) OR MICROSATELLITE INSTABILITY (MSI-H) (IMperator)
CompletedCTIS2024-512635-71-00
Roche Farma S.A.Solid tumors
Start: 2024-03-14End: 2024-12-09Target: 40Updated: 2024-10-28
MICROBIOTA MODIFICATION FOR IMMUNO-ONCOLOGY IN HEPATOCELLULAR CARCINOMA - “MOTHER”
RecruitingCTIS2023-508201-25-00
Centre De Lutte Contre Le Cancer Eugene MarquisHepatocellular carcinoma
Start: 2025-03-12Target: 34Updated: 2025-12-22
AZALEA: A Phase II study of atezolizumab, vinorelbine and weekly cyclophosphamide as T-cell activators in first line metastatic triple negative breast cancer patients pre-treated with anti-PD-L1/PD-1
RecruitingCTIS2024-514031-20-00
Istituto Europeo Di Oncologia S.r.l.Inoperable locally advanced or metastatic TNBC patients, previously treated with anti-PD-L1/PD1- regimens
Start: 2025-02-24Target: 45Updated: 2025-04-14
Preoperative immunotherapy with atezolizumab (Tecentriq®) and tiragolumab in patients with colorectal liver metastases (CRLM) (the PURPLE trial)
SuspendedCTIS2022-503044-40-00
Universitaetsklinikum Essen AöRColorectal liver metastases (CRLM)
Start: 2024-12-16Target: 18Updated: 2025-08-04
Perioperative/Adjuvant atezolizumab in patients with MSI-high or MMRdeficient stage II high risk or stage III colorectal cancer ineligible for oxaliplatin-based chemotherapy– a Phase II study (ANTONIO)
Active, not recruitingCTIS2024-515224-37-00
AIO-Studien gGmbHPatients with MSI-high or MMR-deficient stage III colorectal cancer who are ineligible for or who refuse oxaliplatin-based chemotherapy after R0 tumor resection (main study) or planned resection (sub-study)
Start: 2023-08-29Target: 80Updated: 2025-11-13
Improving public cancer care by implementing precision medicine in Norway A multi-cohort phase 2 treatment clinical study investigating efficacy of approved drugs outside indication in patients with advanced cancer. IMPRESS-Norway
RecruitingCTIS2023-507894-16-00
Oslo University Hospital HFCancer
Start: 2021-04-01Target: 6000Updated: 2026-01-22
Impact of neoadjuvant immunotherapy in early stage breast cancer before standard therapy (BIS-Program)
CompletedCTIS2024-512826-26-00
Institut Gustave RoussyNewly diagnosed, non-metastatic early-stage triple-negative or HER2+ breast cancer
Start: 2022-03-07End: 2024-12-17Target: 185Updated: 2024-09-25
The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs to determine the Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile
Not yet recruitingCTIS2024-517478-68-01
HUS-YhtymaeAdvanced Cancer
Target: 250Updated: 2024-11-06
Integration of the PD-L1 inhibitor atezolizumab and WT1/DC vaccination into platinum/pemetrexed-based first-line treatment for epithelioid malignant pleural mesothelioma
RecruitingCTIS2024-515293-27-00
Antwerp University Hospitalepithelioid subtype (stage I-IV), Malignant pleural mesothelioma
Start: 2023-02-24Target: 15Updated: 2026-01-22
Biomarker discovery randomized phase IIb trial with carboplatin-cyclophosphamide versus paclitaxel with or without atezolizumab as first-line treatment in advanced triple negative breast cancer
Active, not recruitingCTIS2024-516202-39-00
BOOG Study Center B.V.Metastatic breast cancer
Start: 2013-10-10Target: 306Updated: 2024-11-22
Phase II Combination Study of NMS-01940153E and Atezolizumab with or without a prior priming with low dose decitabine for the Treatment of Adult Patients with Unresectable Hepatocellular Carcinoma (HCC) Previously Treated with Immune Checkpoint Inhibitors
Active, not recruitingCTIS2024-516737-12-00
Nerviano Medical Sciences S.r.l.Unresectable Hepatocellular Carcinoma (HCC)
Start: 2025-01-28Target: 90Updated: 2025-08-19

Phase 3

A Phase III, Double-blind, Multicenter, Randomized study of Atezolizumab (anti-PD‑L1 antibody) versus Placebo as Adjuvant therapy in Patients with High-Risk Muscle-Invasive Bladder Cancer who are CTDNA positive following cystectomy
Active, not recruitingCTIS2022-502705-15-00
F. Hoffmann-La Roche AGHigh-risk muscle-invasive bladder cancer
Start: 2021-03-08Target: 112Updated: 2025-07-01
A Phase III, Open-Label, Randomized Study of Atezolizumab and Tiragolumab Compared with Durvalumab in Patients with Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer who have not Progressed after Concurrent Platinum-Based Chemoradiation (SKYSCRAPER-03)
CompletedCTIS2022-502480-38-00
F. Hoffmann-La Roche AGNon−small cell lung cancer (NSCLC)
Start: 2020-09-09End: 2025-07-31Target: 262Updated: 2025-06-12
PANOVA-4: Pilot, Single arm Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant with Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-Line Treatment for Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
CompletedCTIS2024-515407-19-00
Novocure GmbHMetastatic pancreatic ductal adenocarcinoma (mPDAC)
Start: 2023-08-16End: 2026-01-15Target: 72Updated: 2025-11-19
First-line immunotherapy-based standard of care and local ablative treatments for oligometastatic non-small cell lung cancer patients: a randomized, multicentre, open-label phase III study (OliGRAIL)
RecruitingCTIS2023-503326-39-00
Institut Gustave RoussySynchronous oligometastatic non-small cell lung cancer (NSCLC)
Start: 2025-03-06Target: 130Updated: 2025-08-26