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TBAJ-876

DRUG2 trials

Sponsors

Global Alliance for TB Drug Development

Conditions

Drug Sensitive TuberculosisDrug-resistant TuberculosisMulti Drug Resistant TuberculosisMycobacterium Tuberculosis InfectionPulmonary DiseasePulmonary TBPulmonary TuberculosisTuberculosis

Phase 1

A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults
CompletedNCT05526911
Global Alliance for TB Drug DevelopmentDrug-resistant Tuberculosis, Drug Sensitive Tuberculosis, Multi Drug Resistant Tuberculosis +4
Start: 2022-06-30End: 2022-09-26Updated: 2024-10-08

Phase 2

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis
Active, not recruitingNCT06058299
Global Alliance for TB Drug DevelopmentDrug Sensitive Tuberculosis, Pulmonary TB, Pulmonary Tuberculosis
Start: 2023-10-24End: 2026-06-30Updated: 2025-02-17

Related Papers

Cardiodynamic evaluation of sorfequiline (TBAJ-876): results from a first-in-human study
Antimicrobial Agents and Chemotherapy2026-01-30
Protocol for a phase 2, partially blinded, randomized trial assessing the safety and efficacy of sorfequiline or bedaquiline in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis (NC-009).
2026-01-06
Contribution of telacebec to novel drug regimens in a murine tuberculosis model
Antimicrobial Agents and Chemotherapy2024-12-094 citations