Tavokinogene Telseplasmid (tavo)

BIOLOGICAL4 trials

Sponsors

OncoSec Medical Incorporated

Conditions

Cutaneous T Cell Lymphomas (CTCL)Head and Neck Squamous Cell CarcinomaMelanomaMerkel Cell CarcinomaMycosis Fungoides (MF)

Phase 2

IL-12 Gene and in Vivo Electroporation-Mediated Plasmid DNA Vaccine Therapy in Patients With Merkel Cell Cancer

CompletedNCT01440816

OncoSec Medical IncorporatedMerkel Cell Carcinoma

Start: 2012-01-03End: 2015-04-10Updated: 2023-05-15

Trial of pIL-12 Electroporation Malignant Melanoma

CompletedNCT01502293

OncoSec Medical IncorporatedMelanoma

Start: 2012-02-14End: 2016-03-21Updated: 2023-05-15

Phase II Intratumoral IL12 Plasmid Electroporation in Cutaneous Lymphoma

TerminatedNCT01579318

OncoSec Medical IncorporatedCutaneous T Cell Lymphomas (CTCL), Mycosis Fungoides (MF)

Start: 2012-06-08End: 2014-06-03Updated: 2023-05-15

Trial of pIL-12 Electroporation in Squamous Cell Carcinoma of the Head and Neck (IL12HNSCC)

TerminatedNCT02345330

OncoSec Medical IncorporatedHead and Neck Squamous Cell Carcinoma

Start: 2015-05-21End: 2016-11-14Updated: 2023-05-15

Related Papers

Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol

Radiology and Oncology2022-05-1022 citations

Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients.

2020-02-01103 citations

Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses

Cancer Immunology Research2019-12-1891 citations

Abstract CT134: Intratumoral electroporation of plasmid IL-12 can prime response to anti-PD1/PD-L1 blockade in patients with Stage III/IV-M1a melanoma

Cancer Research2016-07-156 citations

Systemic antitumor effect and clinical response in a phase 2 trial of intratumoral electroporation of plasmid interleukin-12 in patients with advanced melanoma.

Journal of Clinical Oncology2014-05-2027 citations