Tavapadon
Sponsors
Cerevel Therapeutics LLC, AbbVie, Cerevel Therapeutics, LLC
Conditions
Healthy VolunteerHepatic ImpairmentParkinson DiseaseParkinson's diseaseRenal Impairment
Phase 1
To Evaluate the Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Mild and Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function
CompletedNCT05404529
Start: 2022-04-29End: 2023-01-24Updated: 2023-05-30
To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function
CompletedNCT05404542
Start: 2022-05-10End: 2023-08-14Updated: 2024-04-02
Study to Evaluate the Effects of Cytochrome P450 (CYP) 3A4 Inducer Carbamazepine on Tavapadon Pharmacokinetics in Healthy Adult Participants
CompletedNCT05581823
Start: 2022-10-19End: 2023-02-02Updated: 2023-04-20
Multiple-dose Trial to Determine the Clinical Bioequivalence Between Tavapadon Tablets in Participants With Parkinson's Disease
CompletedNCT05610189
Start: 2022-12-15End: 2023-12-17Updated: 2024-02-08
A Study to Assess the Relative Bioavailability of Oral Tavapadon in Healthy Adult Participants
CompletedNCT06895356
Start: 2025-03-26End: 2025-06-16Updated: 2025-06-26
Phase 3
Fixed-Dose Trial in Early Parkinson's Disease (PD)
CompletedNCT04201093
Start: 2019-12-13End: 2024-06-28Updated: 2025-07-28
Flexible-Dose Trial in Early Parkinson's Disease (PD)
CompletedNCT04223193
Start: 2020-01-06End: 2024-10-01Updated: 2025-11-21
Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TEMPO-3)
CompletedNCT04542499
Start: 2020-09-23End: 2024-02-15Updated: 2025-04-04
Open-label Trial in Parkinson's Disease (PD)
CompletedNCT04760769
Start: 2021-02-24End: 2025-12-01Updated: 2025-12-23
58-week Open-Label Trial of Tavapadon in Parkinson’s Disease (Tempo-4 Trial)
CompletedCTIS2024-512123-37-00
Start: 2021-05-27End: 2025-12-01Target: 487Updated: 2025-11-26