Tapentadol

DRUG16 trials

Sponsors

Higashi Sapporo Hospital, Grünenthal GmbH, Janssen Pharmaceutical K.K., Mayo Clinic, Tris Pharma, Inc.

Conditions

Acute PainAcute Postoperative PainAnalgesics, Antipyretics, and Antirheumatics Causing Adverse Effects in Therapeutic UseArthroscopic Rotator Cuff Repair (ARCR)Breakthrough Cancer PainBreast CancerBunionCancer Pain

Phase 1

Phase 1 Pharmacokinetic Study of Tapentadol Prolonged-Release 250 Milligram (mg) Formulation in Healthy Participants

CompletedNCT01877226

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.Healthy

Start: 2008-09-30End: 2008-10-31Updated: 2013-06-13

Phase 2

A Phase 2 Study of Tapentadol Extended-Release (JNS024ER) ) in Japanese Participants With Chronic Pain Due to Diabetic Neuropathic Pain or Postherpetic Neuralgia

CompletedNCT01124617

Janssen Pharmaceutical K.K.Diabetic Neuropathies, Neuralgia, Pain +1

Start: 2010-06-30End: 2011-04-30Updated: 2014-01-13

Intravenous Tapentadol in Post-Bunionectomy Pain

CompletedNCT01435577

Grünenthal GmbHBunion, Pain

Start: 2011-09-30End: 2012-02-29Updated: 2019-10-28

Efficacy and Safety of GRT6005 in Patients With Chronic Low Back Pain.

CompletedNCT01725087

Tris Pharma, Inc.Low Back Pain

Start: 2012-11-30End: 2014-07-31Updated: 2021-07-15

Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain

CompletedNCT01729728

Grünenthal GmbHAcute Pain, Postoperative Pain

Start: 2012-11-30End: 2014-02-28Updated: 2019-11-04

Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old

TerminatedNCT02221674

Grünenthal GmbHModerate to Severe Acute Postoperative Pain

Start: 2014-11-05End: 2016-11-03Updated: 2018-01-29

Effect of tapentadol for the cancer pain

Active, not recruitingJPRN-UMIN000016414

Higashi Sapporo Hospitalcancer patients

Start: 2015-02-02Target: 80Updated: 2026-06-29

Phase 3

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic

CompletedNCT00983073

Grünenthal GmbHChronic Pain, Osteoarthritis

Start: 2009-09-30End: 2010-09-30Updated: 2019-10-21

Depot-opioids for Pre- and Postoperative Pain Relief After Primary Knee Arthroplasty.Tapentadol vs Oxycodone vs Placebo

CompletedNCT02604446

St. Olavs HospitalJoint Diseases

Start: 2015-09-30End: 2019-02-28Updated: 2021-11-16

Phase 4

Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans

CompletedNCT01500317

Mayo ClinicEffects of 2 Mu-opiates on Gastrointestinal Transit

Start: 2011-05-31End: 2011-12-31Updated: 2012-12-17

Effects of Tapentadol Versus Oxycodone After Hysterectomy.

CompletedNCT03314792

Oslo University HospitalAnalgesics, Antipyretics, and Antirheumatics Causing Adverse Effects in Therapeutic Use, Opioid Use, Pain, Acute +3

Start: 2017-12-04End: 2019-02-28Updated: 2019-04-04

Tapentadol vs Tramadol in Total Knee Arthroplasty

RecruitingNCT06269770

University of ThessalyChronic Pain, Post-operative Pain, Total Knee Replacement

Start: 2023-05-01End: 2025-06-01Target: 96Updated: 2024-05-14

Unknown Phase

Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain

CompletedNCT01946555

Mario Negri Institute for Pharmacological ResearchBreakthrough Cancer Pain, Cancer Pain, Neuropathic Pain +1

Start: 2013-09-30End: 2015-12-31Updated: 2016-04-14

Role of Preoperative Tapentadol in Reduction of Perioperative Analgesic Requirement After Breast Conservative Surgery in Cancer Patients.

CompletedNCT07320781

Shaukat Khanum Memorial Cancer Hospital & Research CentreBreast Cancer

Start: 2024-11-15End: 2025-10-10Updated: 2026-01-08

Tapentadol vs Pregabalin for Postoperative Pain in Lower Limb Surgery

CompletedNCT07587645

ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"Acute Postoperative Pain, Lower Limb Surgery

Start: 2024-06-19End: 2024-07-05Updated: 2026-05-15

Tapentadol vs Tramadol in Arthroscopic Rotator Cuff Repair

Active, not recruitingNCT07779473

University of ThessalyArthroscopic Rotator Cuff Repair (ARCR), Chronic Pain, Postoperative Pain

Start: 2026-07-01End: 2029-09-01Target: 64Updated: 2026-08-21

Related Papers

A Web-Based Communication Tool for Postoperative Follow-up and Pain Assessment at Home After Primary Knee Arthroplasty: Feasibility and Usability Study

JMIR Formative Research2022-03-149 citations

Tapentadol for the Treatment of Moderate-to-Severe Acute Pain in Children Under the Age of Two Years.

2021-01-298 citations

Tapentadol versus oxycodone analgesia and side effects after laparoscopic hysterectomy

European Journal of Anaesthesiology2021-01-078 citations

Effectiveness and safety of tapentadol prolonged release with tapentadol immediate release on-demand for the management of severe, chronic osteoarthritis-related knee pain: results of an open-label, phase 3b study.

2012-06-1529 citations