Tafolecimab

DRUG8 trials

Conditions

Acute Coronary SyndromeAcute Myocardial Infarction (AMI)Bladder CancerBladder Urothelial CarcinomaCapecitabineExtensive Disease Small Cell Lung CancerExtensive Stage Lung Small Cell CancerExtensive-Stage Small-Cell Lung Cancer

Phase 2

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

RecruitingNCT06421298

Jinghui WangLung Cancer

Start: 2024-05-17End: 2027-05-30Target: 30Updated: 2024-05-20

Sintilimab Combined With Tafolecimab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer

RecruitingNCT07061535

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityExtensive-stage Small Cell Lung Cancer (ES-SCLC), Extensive Stage Lung Small Cell Cancer, Extensive-Stage Small-Cell Lung Cancer +1

Start: 2025-07-30End: 2027-08-01Target: 40Updated: 2026-06-23

Sun Yat-Sen Treatment Strategy for Enhancing Response in Muscle-invasive Bladder Cancer

RecruitingNCT07717242

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityBladder Urothelial Carcinoma, Bladder Cancer

Start: 2026-07-01End: 2029-01-31Target: 80Updated: 2026-07-21

Phase 3

Anti-PCSK9 Antibody Tafolecimab and Anti-PD-1 Antibody Sintilimab Combined With Neoadjuvant Chemoradiotherapy for pMMR/ MSS Locally Advanced Rectal Cancer : A Prospective, Multicenter, Randomized, Open-Label, Parallel-Controlled Trial

Not yet recruitingNCT07686796

Guangdong Provincial People's HospitalLocal Advanced Rectal Cancer, PD-1 Inhibitor, PCSK9 Inhibitor +4

Start: 2027-01-01End: 2035-01-01Target: 148Updated: 2026-07-07

Phase 4

Effectiveness of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor Initiation Before Percutaneous Coronary Intervention on Acute Myocardial Infarction Patients

Not yet recruitingNCT06683131

The Affiliated Hospital of Xuzhou Medical UniversityAcute Myocardial Infarction (AMI)

Start: 2025-11-20End: 2027-11-30Target: 1160Updated: 2025-11-21

Unknown Phase

Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population

Not yet recruitingNCT06096909

China National Center for Cardiovascular DiseasesAcute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome

Start: 2023-11-01End: 2027-11-01Target: 3684Updated: 2023-10-24

INtensive liPid-lowering Therapy for Acute High-risk IntracRanial or Extracranial atheroSclerosis -II (INSPIRES-2)

Not yet recruitingNCT07341958

Beijing Tiantan HospitalIschemic Stroke or High-risk TIA (ABCD² ≥ 4)

Start: 2026-02-01End: 2027-08-30Target: 242Updated: 2026-01-15

Tafolecimab in Hyperlipidemia: A Study of Different Dosing Intervals

Not yet recruitingNCT07712042

Mei GaoHyperlipidemia