Tafenoquine
Sponsors
GlaxoSmithKline, U.S. Army Medical Research and Development Command, 60 Degrees Pharmaceuticals LLC, Menzies School of Health Research, University of Oxford
Conditions
BabesiosisFalciparum ParasitaemiaG6PD DeficiencyHealthy Lactating WomenHealthy VolunteersMalariaMalaria RelapseMalaria, Vivax
Phase 1
G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)
CompletedNCT01205178
Start: 2009-07-02End: 2013-04-01Updated: 2017-06-07
A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate
CompletedNCT02184637
Start: 2014-07-31End: 2015-04-08Updated: 2017-07-13
Phase 2
Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults
TerminatedNCT01290601
Start: 2003-09-15End: 2005-01-10Updated: 2018-02-23
Study to Evaluate the Efficacy and Safety of Tafenoquine for the Treatment of Plasmodium Vivax in Adults
TerminatedNCT01290601
Start: 2003-09-15End: 2005-01-10Updated: 2018-02-23
An Evaluation of Weekly Tafenoquine
CompletedNCT02488980
Start: 2000-05-31End: 2003-03-31Updated: 2017-05-30
Evaluation of Weekly Tafenoquine
CompletedNCT02491606
Start: 1997-05-31End: 1998-09-30Updated: 2018-09-13
A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria
CompletedNCT02563496
Start: 2017-02-06End: 2020-02-17Updated: 2020-11-02
Long-Term Safety Study of Tafenoquine
CompletedNCT03320174
Start: 2017-10-05End: 2021-07-13Updated: 2021-08-26
Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali
CompletedNCT05081089
Start: 2021-10-12End: 2022-01-13Updated: 2022-01-18
Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis
RecruitingNCT06207370
Start: 2024-06-17End: 2027-07-01Target: 33Updated: 2025-11-21
Phase 3
Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria
CompletedNCT02216123
Start: 2015-04-30End: 2016-11-04Updated: 2018-05-16
Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria
CompletedNCT02802501
Start: 2018-04-08End: 2019-08-19Updated: 2020-07-24
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
CompletedNCT04411836
Start: 2021-04-25End: 2024-09-30Updated: 2024-10-08
A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
RecruitingNCT06148792
Start: 2024-05-10End: 2027-03-01Target: 1090Updated: 2025-07-18
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
RecruitingNCT06666491
Start: 2024-11-13End: 2026-05-25Target: 300Updated: 2025-08-07
Phase 4
Southeast Asia Dose Optimization of Tafenoquine
RecruitingNCT04704999
Start: 2024-07-22End: 2028-02-07Target: 700Updated: 2025-03-06
Tafenoquine and Primaquine in Colostrum and Breast Milk
WithdrawnNCT04984759
Start: 2023-07-01End: 2025-06-30Updated: 2024-04-04
Vivax Elimination With Tafenoquine (VET) Study
CompletedNCT06575647
Start: 2025-02-19End: 2025-10-04Updated: 2026-01-06
Unknown Phase
Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in Brazil
NCT05096702
Start: 2021-09-09End: 2023-09-09Updated: 2023-06-13
Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand
CompletedNCT05753150
Start: 2022-05-23End: 2023-10-01Updated: 2023-10-26
Expanded Use in Persistent (B. Microti) Babesiosis
NCT06478641
Updated: 2025-11-21