T-DXd
Sponsors
AstraZeneca, Daiichi Sankyo, Beijing 302 Hospital, Fudan University, SOLTI Breast Cancer Research Group
Conditions
Advanced CancerAdvanced Solid TumorBreast CancerBreast Cancer Stage IVGastric AdenocarcinomaGastroesophageal Junction AdenocarcinomaHER2 Low Metastatic Breast CancerHER2-positive Breast Cancer
Phase 1
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
RecruitingNCT04686305
Start: 2021-03-09End: 2027-06-30Target: 304Updated: 2026-04-13
A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors
RecruitingNCT05765851
Start: 2023-05-30End: 2030-05-15Target: 108Updated: 2026-08-21
A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors
Active, not recruitingNCT06244485
Start: 2024-02-16End: 2028-11-01Updated: 2026-07-21
Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases
RecruitingNCT07134153
Start: 2025-04-18End: 2027-02-28Target: 139Updated: 2025-08-21
Trastuzumab Deruxtecan Plus Nivolumab Plus Capecitabine Plus Oxaliplatin for HER2 Low Gastric and Gastroesophageal Junction Adenocarcinoma
CompletedNCT07529613
Start: 2023-12-20End: 2025-12-31Updated: 2026-04-14
Study of Trastuzumab Deruxtecan (T-DXd) in Combination With a RAGE Inhibitor in Patients With T-DXd-Resistant HER2-Positive or HER2-Low Metastatic Breast Cancer
Not yet recruitingNCT07785856
Start: 2026-12-01End: 2029-12-01Target: 27Updated: 2026-08-25
Phase 2
T-DXd Versus THP for Medium-risk HER2-positive Early Breast Cancer
Not yet recruitingNCT06548178
Start: 2024-09-30End: 2028-09-30Target: 242Updated: 2024-08-12
Trastuzumab Deruxtecan in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management
RecruitingNCT07371585
Start: 2026-02-18End: 2030-07-01Target: 300Updated: 2026-03-27
SHR-A1811 vs Pyrotinib/Capecitabine in Trastuzumab-Resistant HER2+ Advanced Breast Cancer: A Randomized Study
Not yet recruitingNCT07417241
Start: 2026-03-31End: 2029-12-31Target: 100Updated: 2026-02-18