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T-DXd

DRUG11 trials

Sponsors

AstraZeneca, Daiichi Sankyo, Beijing 302 Hospital, Fudan University, SOLTI Breast Cancer Research Group

Conditions

Advanced CancerAdvanced Solid TumorBreast CancerBreast Cancer Stage IVGastric AdenocarcinomaGastroesophageal Junction AdenocarcinomaHER2 Low Metastatic Breast CancerHER2-positive Breast Cancer

Phase 1

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
RecruitingNCT04686305
AstraZenecaLocally Advanced or Metastatic Non-Small Cell Lung Cancer
Start: 2021-03-09End: 2027-06-30Target: 304Updated: 2026-04-13
A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors
RecruitingNCT05765851
Daiichi SankyoAdvanced Solid Tumor
Start: 2023-05-30End: 2030-05-15Target: 108Updated: 2026-08-21
A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors
Active, not recruitingNCT06244485
Daiichi SankyoAdvanced Solid Tumor
Start: 2024-02-16End: 2028-11-01Updated: 2026-07-21
Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases
RecruitingNCT07134153
Fudan UniversityBreast Cancer
Start: 2025-04-18End: 2027-02-28Target: 139Updated: 2025-08-21
Trastuzumab Deruxtecan Plus Nivolumab Plus Capecitabine Plus Oxaliplatin for HER2 Low Gastric and Gastroesophageal Junction Adenocarcinoma
CompletedNCT07529613
National Cancer Center Hospital EastGastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Start: 2023-12-20End: 2025-12-31Updated: 2026-04-14
Study of Trastuzumab Deruxtecan (T-DXd) in Combination With a RAGE Inhibitor in Patients With T-DXd-Resistant HER2-Positive or HER2-Low Metastatic Breast Cancer
Not yet recruitingNCT07785856
The Methodist Hospital Research InstituteT-dxd Resistant HER2-Positive, HER2 Low Metastatic Breast Cancer
Start: 2026-12-01End: 2029-12-01Target: 27Updated: 2026-08-25

Phase 2

Phase 3

Unknown Phase

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