Systemic treatment

DRUG9 trials

Conditions

Breast CancerCervical AdenocarcinomaCervical Adenosquamous CarcinomaColon CancerCutaneous Squamous Cell Carcinoma (CSCC)Hepatocellular CarcinomaMetastasisMetastatic Breast Cancer

Phase 1

RT for Adenocarcinoma/Adenosquamous Carcinoma

Active, not recruitingNCT07153952

Peking Union Medical College HospitalCervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Radiotherapy

Start: 2025-01-01End: 2028-01-01Target: 60Updated: 2025-09-04

Phase 2

Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients With Metastatic Cancers

WithdrawnNCT03323424

Institut de Cancérologie de la LoireMetastatic Breast Cancer, Metastatic Colorectal Cancer, Metastatic Head and Neck Cancer

Start: 2019-01-01End: 2026-02-01Updated: 2020-01-30

HAIC Plus Toripalimab vs. HAIC Plus Sorafenib for HCC With PVTT: a Non-comparative, Prospective, Randomized Trial

NCT04135690

Sun Yat-sen UniversityHepatocellular Carcinoma

Start: 2019-10-20End: 2023-12-20Target: 60Updated: 2023-08-15

Phase 3

The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer

CompletedNCT01606098

Dutch Colorectal Cancer GroupColon Cancer, Primary Tumour, Rectal Cancer

Start: 2012-07-31End: 2022-12-31Updated: 2023-09-13

Trial of Superiority of Stereotactic Body Radiation Therapy in Patients With Breast Cancer

Active, not recruitingNCT02089100

Gustave Roussy, Cancer Campus, Grand ParisBreast Cancer

Start: 2014-02-26End: 2034-10-01Updated: 2026-03-19

Unknown Phase

Intervention to Hepatic and Pulmonary Metastasis in Breast Cancer Patients

NCT02251353

Federation of Breast Diseases SocietiesBreast Cancer, Metastasis

Start: 2014-06-30End: 2022-06-30Target: 300Updated: 2020-02-21

Study for Novel Coronavirus Pneumonia (NCP)

NCT04283396

Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNovel Coronavirus Pneumonia

Start: 2020-02-21End: 2020-07-30Target: 2000Updated: 2020-03-17

Survival Analysis: TACE vs. Combination Therapy in HCC

CompletedNCT06261138

Zhejiang UniversityHepatocellular Carcinoma

Start: 2019-02-01End: 2023-10-31Updated: 2024-02-15

Follow-up of a French National Cohort of Patients With Cutaneous Squamous Cell Carcinoma Requiring Systemic Treatment.

RecruitingNCT07606508

University Hospital, LilleCutaneous Squamous Cell Carcinoma (CSCC)

Start: 2021-07-09End: 2036-07-15Target: 1500Updated: 2026-05-26

Journal of Clinical Oncology2026-05-27

Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group.

2024-06-079 citations

Upfront palliative resection of primary tumor versus no resection in patients with synchronous metastatic colorectal cancer: The randomized phase 3 CAIRO4 study of the Dutch Colorectal Cancer Group (DCCG).

Journal of Clinical Oncology2023-06-015 citations

Sixty-Day Mortality of Patients With Metastatic Colorectal Cancer Randomized to Systemic Treatment vs Primary Tumor Resection Followed by Systemic Treatment

JAMA Surgery2021-10-0951 citations

Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients with Oligometastatic Breast Cancer: Study protocol for a randomized controlled multi-national and multi-center clinical trial (OLIGOMA)

Clinical and Translational Radiation Oncology2021-04-0530 citations

The Role of Primary Tumor Resection in Colorectal Cancer Patients with Asymptomatic, Synchronous, Unresectable Metastasis: A Multicenter Randomized Controlled Trial

Cancers2020-08-1656 citations

A randomized controlled trial comparing primary tumour resection plus chemotherapy with chemotherapy alone in incurable stage IV colorectal cancer: JCOG1007 (iPACS study)

Japanese Journal of Clinical Oncology2019-11-1944 citations

The CAIRO4 study: The role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer—A randomized phase III study of the Dutch Colorectal Cancer Group (DCCG).

Journal of Clinical Oncology2016-02-012 citations

Journal of Clinical Oncology2015-05-206 citations

The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer--a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG).

2014-10-0261 citations