SYN023

BIOLOGICAL4 trials

Conditions

Communicable DiseaseHuman RabiesMononegavirales InfectionsRNA Virus InfectionsRabiesRabies Post-exposure ProphylaxisRhabdoviridae InfectionsVirus Diseases

Phase 1

A Comparison of the Safety, PD and PK of a Single Dose of SYN023 Administered With Licensed Rabies Vaccines

CompletedNCT02956746

Synermore Biologics Co., Ltd.Human Rabies

Start: 2016-08-31End: 2018-01-31Updated: 2019-02-27

SYN023 With Rabies Vaccine in Healthy Pediatric Subjects

CompletedNCT07342257

Synermore Biologics (Suzhou) Co., Ltd.Rabies Post-exposure Prophylaxis

Start: 2024-11-30End: 2025-07-23Updated: 2026-01-15

Phase 2

Comparison of SYN023 to Human Rabies Immune Globulin in Post Exposure Prophylaxis of Rabies

CompletedNCT03961555

Synermore Biologics Co., Ltd.Rabies

Start: 2019-09-03End: 2021-12-23Updated: 2026-01-16

Phase 3

A Phase III Clinical Study to Evaluate SYN023's Efficacy and Safety

CompletedNCT04644484

Synermore Biologics (Suzhou) Co., Ltd.Communicable Disease, Mononegavirales Infections, Rabies +3

Start: 2020-09-23End: 2022-12-16Updated: 2023-04-21

Related Papers

The pharmacokinetics and safety comparison of Zamerovimab and Mazorelvimab monoclonal antibodies vs. HRIG in category III rabies post-exposure prophylaxis: a stratified analysis by wound characteristics

Biologicals2025-08-13

The efficacy and safety of SYN023 (Zamerovimab and Mazorelvimab injection), the recombinant humanized anti-rabies virus monoclonal antibody mixture, combined with rabies vaccine in a WHO category III rabies post-exposure population: A randomized, double-blind, positive control, phase III clinical trial.

2025-06-051 citations

A phase 2b, Randomized, double blinded comparison of the safety and efficacy of the monoclonal antibody mixture SYN023 and human rabies immune globulin in patients exposed to rabies.

2024-06-047 citations

Rabies virus neutralizing activity, pharmacokinetics, and safety of the monoclonal antibody mixture SYN023 in combination with rabies vaccination: Results of a phase 2, randomized, blinded, controlled trial.

2021-09-0316 citations