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SV-BR-1-GM

BIOLOGICAL3 trials

Sponsors

BriaCell Therapeutics Corporation

Conditions

Breast CancerBreast Cancer MetastaticBreast NeoplasmBreastcancerEnd Stage CancerMetastatic Breast Cancer

Phase 1

SV-BR-1-GM in Metastatic or Locally Recurrent Breast Cancer
CompletedNCT03066947
BriaCell Therapeutics CorporationBreastcancer, Breast Neoplasm
Start: 2017-05-05End: 2018-11-22Updated: 2021-01-29
Combination Study of SV-BR-1-GM With Retifanlimab
CompletedNCT03328026
BriaCell Therapeutics CorporationBreast Cancer, Breast Cancer Metastatic, Breast Neoplasm +1
Start: 2018-03-16End: 2026-03-24Updated: 2026-03-27

Phase 3

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingNCT06072612
BriaCell Therapeutics CorporationBreast Cancer, Breast Cancer Metastatic, Breast Neoplasm +2
Start: 2023-12-05End: 2028-06-01Target: 404Updated: 2026-04-02

Related Papers

Abstract PS1-13-23: Survival Results of Phase II Bria-IMT Allogenic Whole Cell-Based Cancer Vaccine
Clinical Cancer Research2026-02-17
Abstract PS1-13-22: Impact of Prior Therapy, Genotype Matching, and Biomarkers in the Bria-ABC Phase 3 Trial
Clinical Cancer Research2026-02-17
Abstract P5-10-12: Bria-IMT CD8+ Tumor Infiltrating Lymphocytes Turn “Cold” Tumor “Hot” in Metastatic Breast Cancer
Clinical Cancer Research2025-06-13
Abstract P2-10-24: ASTRO-VAC CNS : Bria-IMT in the Management of Tumor Agnostic Metastatic CNS Lesions
Clinical Cancer Research2025-06-13
Abstract PS3-04: Overall Survival Results of Bria-IMT Allogenic Whole Cell-Based Cancer Vaccine
Clinical Cancer Research2025-06-13
Abstract P1-01-17: PD-L1 Upregulation in Circulating Tumor Associated Cells Predicts for clinical outcomes in a phase I/II clinical trial using SV-BR-1-GM vaccine with the check point inhibitor retifanlimab in Metastatic Breast Cancer Patients, an Interim Analysis
Clinical Cancer Research2025-06-13
Bria-IMT + checkpoint inhibitor: Phase I/II survival results compared to benchmark trials in metastatic breast cancer.
Journal of Clinical Oncology2025-05-28
Impact of HLA matching on clinical outcomes in a phase 2 trial of Bria-IMT plus anti PD1 in advanced breast cancer.
Journal of Clinical Oncology2025-05-28
Update on phase III pivotal trial of Bria-IMT + CPI vs physician’s choice in advanced metastatic breast cancer (BRIA-ABC).
Journal of Clinical Oncology2025-05-28
Abstract LB408: <i>Bria-</i>ABC vs physician choice in late stage MBC: Early biomarker correlates of the randomized registration trial
Cancer Research2025-04-25
Abstract CT100: Survival outcomes in a randomized phase 2 of<i>Bria-IMT</i>: An allogeneic whole cell cancer vaccine
Cancer Research2025-04-25
Study of the Bria-IMT regimen and CPI vs physicians' choice in advanced metastatic breast cancer (BRIA-ABC).
Journal of Clinical Oncology2024-06-011 citations
Outcomes of advanced/metastatic breast cancer (aMBC) treated with BRIA-IMT, an allogeneic whole cell immunotherapy.
Journal of Clinical Oncology2024-06-011 citations
SV-BR-1-GM after progression on ADC in patients with metastatic breast cancer.
Journal of Clinical Oncology2024-06-01
Differential efficacy of SV-BR-1-GM in inducing intracranial metastasis regression.
Journal of Clinical Oncology2024-06-01
Abstract PO2-13-06: Analysis of Antibody Response to SV-BR-1-GM Therapeutic Vaccine in Breast Cancer Patients Using Human Protein Microarrays: Potential Correlations with Therapy Response
Cancer Research2024-05-021 citations
Abstract PO3-05-12: Randomized Phase 2 of Bria-IMT, an Allogenic Human Cell Line with Antigen Presenting Activity, in Heavily Pretreated Metastatic Breast Cancer
Cancer Research2024-05-02
Abstract PO1-20-12: CD8+ Tumor Infiltrating Lymphocytes Turn a Cold Tumor Hot in Metastatic Breast Cancer
Cancer Research2024-05-02
Abstract CT143: Whole cell antigen presenting immune stimulating cells (Bria-IMT) for the treatment of metastatic breast cancer
Cancer Research2023-04-14
Abstract P3-07-12: Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell Therapeutic Vaccine in Advanced Metastatic Breast Cancer
Cancer Research2023-03-01

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