sulfadoxine-pyrimethamine (SP)

DRUG3 trials

Sponsors

University of California, San Francisco, London School of Hygiene and Tropical Medicine, Grant Dorsey, M.D, Ph.D.

Conditions

Cardiac SafetyCardiotoxicityMalariaParasitemiaPregnancy Malaria

Phase 2

Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania

CompletedNCT02909712

London School of Hygiene and Tropical MedicineCardiac Safety, Cardiotoxicity, Malaria +2

Start: 2016-09-30End: 2020-02-29Updated: 2021-02-02

Phase 3

Chemopreventive Therapy for Malaria in Ugandan Children

CompletedNCT00948896

University of California, San FranciscoMalaria

Start: 2010-06-30End: 2014-04-30Updated: 2015-11-24

Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda

CompletedNCT04336189

Grant Dorsey, M.D, Ph.D.Malaria

Start: 2020-12-28End: 2024-07-28Updated: 2025-11-06

Related Papers

Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda

PLoS Medicine2025-09-185 citations

Study protocol.

OPAL (Open@LaTrobe) (La Trobe University)2025-09-18

Statistical analysis plan.

OPAL (Open@LaTrobe) (La Trobe University)2025-09-18

Malaria burden in a birth cohort of HIV-exposed uninfected Ugandan infants living in a high malaria transmission setting.

2016-10-182 citations

Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

Malaria Journal2015-09-2424 citations

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens

Malaria Journal2015-02-046 citations

Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial

PLoS Medicine2014-08-05112 citations

Fitness Consequences of <i>Plasmodium falciparum pfmdr1</i> Polymorphisms Inferred from <i>Ex Vivo</i> Culture of Ugandan Parasites

Antimicrobial Agents and Chemotherapy2013-06-2522 citations