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Standard of Care Radiation Therapy

RADIATION3 trials

Sponsors

Wake Forest University Health Sciences, Sabine Mueller, MD, PhD, NRG Oncology

Conditions

Breast CancerCNS TumorCentral Nervous System TumorDiffuse Midline Glioma (DMG)GlioblastomaNon Small Cell Lung CancerOligoprogressiveRecurrent Ependymoma

Phase 1

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
RecruitingNCT04732065
Sabine Mueller, MD, PhDCentral Nervous System Tumor, CNS Tumor, Diffuse Midline Glioma (DMG) +5
Start: 2021-08-23End: 2027-07-31Target: 208Updated: 2026-03-17

Phase 2

Local Consolidative Radiotherapy for Oligoprogressive in Non-small Cell Lung Carcinoma
WithdrawnNCT04485026
Wake Forest University Health SciencesNon Small Cell Lung Cancer, Oligoprogressive
Start: 2020-11-04End: 2024-05-09Updated: 2025-04-17

Phase 3

Assessment of Biosignature Classification of DCIS for RadioTherapy Benefit Post Lumpectomy (ABCD RT)
Not yet recruitingNCT07554573
NRG OncologyBreast Cancer
Start: 2026-06-30End: 2048-07-31Target: 5270Updated: 2026-04-28

Related Papers

Abstract PS4-07-19: An agonist of mitochondrial CLPP, ONC206, overcomes mitochondrial dependencies and abates chemoresistance in triple negative breast cancer
Clinical Cancer Research2026-02-17
EXTH-70. ONC206 inhibits tumor growth and is a potential novel therapeutic strategy for refractory medulloblastoma
Neuro-Oncology2025-11-01
Abstract 6400: Preclinical efficacy of combinatorial B7-H3 CAR T cell and ONC206 treatment in DIPG/DMG
Cancer Research2025-04-21
Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT
Oncotarget2025-03-275 citations
Omnigene-Gut<sup>tm</sup> ensures fecal microbiome stability in the pediatric population.
2024-12-06
DIPG-11. PRECLINICAL EFFICACY OF B7-H3 CAR T CELLS IN COMBINATION WITH ONC206
Neuro-Oncology2024-06-18
Co-treatment of human GBM cell lines with imipridone ONC206 and tumor treating fields: Effect on on cell death and p-AKT.
Journal of Clinical Oncology2024-06-01
Abstract 3331: Preclinical combination of ONC206 with radiotherapy and temozolomide in a GBM mouse orthotopic model
Cancer Research2024-03-221 citations
Abstract 3173: Impact of hypoxia on the integrated stress response activated by imipridones ONC201 and ONC206 in pediatric diffuse midline glioma cells
Cancer Research2024-03-22
Abstract 7596: (TTFields) and imipridone ONC206 co-treatment inhibits p-AKT and spheroid growth and upregulates caspase-10 in human GBM cell lines
Cancer Research2024-03-22
Abstract A050: Ferritin, associated with worse overall survival in recurrent GBM, is reduced by combination of HDACi, ONC206 and radiation
Cancer Research2024-03-04
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma
Cancer Research2023-05-0574 citations
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
Neuro-Oncology2022-02-1191 citations