Standard Dose Radiation

RADIATION3 trials

Sponsors

Icahn School of Medicine at Mount Sinai, University of Chicago, Hai-Qiang Mai,MD,PhD

Conditions

HPV-Negative Squamous Cell CarcinomaNasopharyngeal Cancinoma (NPC)Squamous Cell Carcinomas

Phase 1

Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer

RecruitingNCT06005324

University of ChicagoHPV-Negative Squamous Cell Carcinoma

Start: 2023-12-18End: 2026-12-31Target: 36Updated: 2025-06-08

Phase 3

The Quarterback Trial: Reduced Dose Radiotherapy for HPV+ Oropharynx Cancer

Active, not recruitingNCT01706939

Icahn School of Medicine at Mount SinaiSquamous Cell Carcinomas

Start: 2012-09-01End: 2035-05-01Updated: 2026-04-09

Reduced Dose Radiotherapy vs Standard Dose Radiotherapy for Early Stage Nasopharyngeal Carcinoma

RecruitingNCT06912698

Hai-Qiang Mai,MD,PhDNasopharyngeal Cancinoma (NPC)

Start: 2025-05-22End: 2033-03-19Target: 342Updated: 2025-04-22

Related Papers

The Quarterback trials: A phase 2 series of sequential studies of induction chemotherapy followed by reduced dose chemoradiation for human papillomavirus positive oropharynx cancer.

Journal of Clinical Oncology2023-06-015 citations

Quality of Life Analysis of HPV-Positive Oropharyngeal Cancer Patients in a Randomized Trial of Reduced-Dose Versus Standard Chemoradiotherapy: 5-Year Follow-Up

Frontiers in Oncology2022-04-0810 citations

Survival (OS) and progression-free survival (PFS) results after induction chemotherapy (IC) followed by de-escalated chemoradiotherapy (RDCRT) for locally advanced (LA) HPV positive oropharynx cancer (HPVOPC.

Journal of Clinical Oncology2021-05-206 citations

Quality of life (QoL) analysis in HPV positive oropharynx cancer (HPVOPC) patients in a randomized deintensification trial.

Journal of Clinical Oncology2018-05-20

Standard of care vs reduced-dose chemoradiation after induction chemotherapy in HPV+ oropharyngeal carcinoma patients.

Journal of Clinical Oncology2017-05-2012 citations

The current and future impact of human papillomavirus on treatment of squamous cell carcinoma of the head and neck.

2014-07-2359 citations