Standard adjuvant systemic chemotherapy

DRUG3 trials

Sponsors

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Fudan University, University of Roma La Sapienza

Conditions

Colon CancerColorectal NeoplasmsIntraperitoneal Rectal CancerLocally Advanced Colorectal CancerPeritoneal Neoplasms

Phase 3

Adjuvant HIPEC in High Risk Colon Cancer

CompletedNCT02231086

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Colorectal Neoplasms, Peritoneal Neoplasms

Start: 2015-03-31End: 2019-06-01Updated: 2021-09-16

Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus no HIPEC in Locally Advanced Colorectal Cancer (APEC Study)

Fudan UniversityLocally Advanced Colorectal Cancer

Start: 2016-11-30End: 2023-11-30Target: 147Updated: 2018-06-19

Proactive Management of Endoperitoneal Spread in Colonic Cancer

University of Roma La SapienzaColon Cancer, Intraperitoneal Rectal Cancer

Start: 2024-03-01End: 2025-09-30Target: 140Updated: 2023-05-06

Related Papers

Underdiagnosis of positive resection margins and synchronous peritoneal metastases in locally advanced colon cancer: histopathological reassessment of primary resection in the COLOPEC trial

Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin2025-05-15

The measured distance between tumor cells and the peritoneal surface predicts the risk of peritoneal metastases and offers an objective means to differentiate between pT3 and pT4a colon cancer.

2022-09-195 citations

Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial.

2019-07-29215 citations

Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; the COLOPEC 2 randomized multicentre trial.

2019-03-2121 citations

Adjuvant HIPEC in patients with colon cancer at high risk of peritoneal metastases: Primary outcome of the COLOPEC multicenter randomized trial.

Journal of Clinical Oncology2019-01-2927 citations

Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in resected high-risk colon cancer patients – study protocol for the PIPAC-OPC3 Trial. A prospective, controlled phase 2 Study

Pleura and Peritoneum2018-06-0125 citations

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial.

2015-05-2496 citations