Spironolactone (drug)

DRUG7 trials

Sponsors

Emory University, Universidad de los Andes, Chile, University Medical Center Groningen, University of Sao Paulo General Hospital, Starlight Therapeutics Inc.

Conditions

Aortic StenosisCKDCardiovascular DiseasesCongenital DisordersDiabetic Kidney DiseaseGlioblastoma (GBM)HIVHeart Failure

Phase 1

A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First Progression

Not yet recruitingNCT07431216

Starlight Therapeutics Inc.Glioblastoma (GBM)

Start: 2026-05-01End: 2027-05-01Target: 68Updated: 2026-03-30

Phase 2

Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)

RecruitingNCT07304817

University Medical Center GroningenCardiovascular Diseases, CKD, Heart Failure

Start: 2026-04-10End: 2028-02-01Target: 100Updated: 2026-04-16

To Establish Whether Dapagliflozin and Spironolactone in Patients With Severe Aortic Stenosis Undergoing Aortic Valve Replacement, Result in Better Left Ventricular Mass Regression, Myocardial Health and Patient Reported Outcomes

Not yet recruitingNCT07539259

University College, LondonAortic Stenosis

Start: 2026-12-01End: 2030-02-28Target: 445Updated: 2026-05-18

Phase 4

Cardiovascular Protective Effect of Spironolactone in Hemodialysis

Universidad de los Andes, ChileHemodialysis

Updated: 2006-01-16

Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety Study

Not yet recruitingNCT07523867

Hospital de Messejana Dr. Carlos Alberto Studart GomesDiabetic Kidney Disease, Heart Failure, Hyperkalemia

Start: 2026-04-01End: 2026-11-01Target: 60Updated: 2026-05-13

Unknown Phase

Spironolactone in Patients With Single Ventricle Heart

CompletedNCT00211081

Emory UniversityCongenital Disorders

Start: 2004-11-30End: 2008-06-30Updated: 2017-11-06

Spironolactone and XPB-1 Integrity in the TFIIH Complex

Enrolling by invitationNCT07415811

University of Sao Paulo General HospitalHIV

Start: 2024-07-24End: 2027-07-01Target: 12Updated: 2026-02-17