Spermidine

DIETARY_SUPPLEMENT7 trials

Sponsors

Medical University of Graz, University of California, Davis, Chrysea Labs Lda, University of Aarhus, West China Hospital

Conditions

AgingCardiovascular DiseasesCognition DisorderCognitive ImpairmentDiabetes Mellitus, Type 2Diastolic DysfunctionDietary HabitsFormer Smokers

Phase 1

A Randomized Controlled Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)

RecruitingNCT07035626

West China HospitalRadiation-induced Xerostomia

Start: 2025-06-25End: 2026-06-08Target: 58Updated: 2025-06-26

A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation

RecruitingNCT07058974

Icahn School of Medicine at Mount SinaiFormer Smokers, Smokers

Start: 2025-08-25End: 2026-07-01Target: 22Updated: 2025-09-25

Phase 2

Polyamine Treatment in Elderly Patients With Coronary Artery Disease

Active, not recruitingNCT06186102

University of AarhusCardiovascular Diseases, Cognition Disorder, Cognitive Impairment +11

Start: 2024-01-01End: 2027-01-31Target: 180Updated: 2025-11-18

Phase 3

Spermidine Anti-Hypertension Study

Medical University of GrazHypertension

Start: 2020-02-25End: 2024-11-15Target: 46Updated: 2023-01-10

Unknown Phase

Absorption and Digestion Kinetics of Human Metabolites

CompletedNCT05017428

University of California, DavisPostprandial Inflammation

Start: 2021-04-08End: 2021-07-01Updated: 2021-08-23

Bioavailability of Spermidine in Healthy Males

Active, not recruitingNCT06017219

Chrysea Labs LdaHealthy Subjects

Start: 2023-05-05End: 2024-12-14Target: 6Updated: 2024-08-30

Iterative Design Trial to Assess Dietary Supplements and Other Aging-targeted Therapies

Enrolling by invitationNCT07202403

Atria Research and Global Health Institute (ARGHI)Aging, Longevity

Start: 2025-09-30End: 2031-09-30Target: 10Updated: 2025-10-01

Related Papers

POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo.

2025-10-30

Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men

Nutrition Research2024-10-235 citations