Spatially-fractionated Radiation Therapy

RADIATION4 trials

Sponsors

Northwestern University, Mayo Clinic

Conditions

Locally Advanced Oral Cavity Squamous Cell CarcinomaLocally Recurrent Oral Cavity Squamous Cell CarcinomaLung Non-Small Cell CarcinomaMalignant TumorMetastatic Malignant Solid NeoplasmMetastatic Solid TumorOral Cavity Squamous Cell CarcinomaRetroperitoneal Sarcoma

Phase 1

Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma

RecruitingNCT06327477

Northwestern UniversityRetroperitoneal Sarcoma

Start: 2024-04-02End: 2029-07-01Target: 28Updated: 2026-07-07

Phase 2

Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer

Active, not recruitingNCT06660407

Mayo ClinicLung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8

Start: 2024-11-14End: 2027-01-10Updated: 2026-10-15

Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial

Not yet recruitingNCT07783581

Mayo ClinicLocally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma

Start: 2026-09-07End: 2030-04-01Target: 30Updated: 2026-08-25

Unknown Phase

Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors

RecruitingNCT07856394

Mayo ClinicMalignant Tumor, Metastatic Malignant Solid Neoplasm, Metastatic Solid Tumor +2

Start: 2026-09-23End: 2031-09-30Target: 100Updated: 2026-10-26