Skip to content

Spartalizumab

DRUG18 trials

Sponsors

Novartis Pharmaceuticals, Columbia University, Emory University, National Taiwan University Hospital, M.D. Anderson Cancer Center

Conditions

Advanced Hepatocellular CarcinomaAnal CarcinomaBRAF V600 Colorectal CancerCarcinoma of Unknown PrimaryCarcinoma, Non-Small-Cell LungCarcinoma, Renal CellCervical CarcinomaCholangiocarcinoma

Early Phase 1

Phase 1

Phase Ib/II Study of INC280 + PDR001 or PDR001 Single Agent in Advanced HCC
CompletedNCT02795429
Novartis PharmaceuticalsAdvanced Hepatocellular Carcinoma
Start: 2016-06-15End: 2021-06-24Updated: 2023-07-03
Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).
TerminatedNCT03742349
Novartis PharmaceuticalsTriple Negative Breast Cancer (TNBC)
Start: 2019-01-31End: 2023-02-06Updated: 2025-05-18
Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies
TerminatedNCT04000529
Novartis PharmaceuticalsColorectal Cancer, Esophageal SCC, Gastrointestinal Stromal Tumors +2
Start: 2019-07-30End: 2024-01-15Updated: 2025-09-30
Siltuximab and Spartalizumab in Patients With Metastatic Pancreatic Cancer
CompletedNCT04191421
Emory UniversityMetastatic Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
Start: 2020-01-17End: 2023-04-05Updated: 2025-08-22
Ribociclib and Spartalizumab in R/M HNSCC
NCT04213404
National Taiwan University HospitalHead and Neck Squamous Cell Carcinoma
Start: 2020-03-13End: 2025-01-31Target: 13Updated: 2022-04-21
A Phase I/Ib Study of NIZ985 Alone and in Combination With Spartalizumab
TerminatedNCT04261439
Novartis PharmaceuticalsIn Escalation: All Patients With Solid Tumors and Lymphoma, In Expansion: Melanoma, Non-small Cell Lung Cancer
Start: 2020-02-27End: 2023-12-27Updated: 2025-05-06
Study of Select Combinations in Adults With Myelofibrosis
WithdrawnNCT04283526
Novartis PharmaceuticalsMyelofibrosis, PMF, Post-Essential Thrombocythemia Myelofibrosis +2
Start: 2020-11-30End: 2024-04-11Updated: 2021-03-04
A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer
TerminatedNCT04294160
Novartis PharmaceuticalsBRAF V600 Colorectal Cancer
Start: 2020-07-22End: 2024-09-25Updated: 2025-12-24

Phase 2

Safety and Efficacy Study of PDR001 in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma
CompletedNCT02605967
Novartis PharmaceuticalsNasopharyngeal Carcinoma
Start: 2016-04-20End: 2021-02-19Updated: 2022-02-10
Study of Capmatinib and Spartalizumab Combination Therapy vs Docetaxel in Non-small Cell Lung Cancer
CompletedNCT03647488
Novartis PharmaceuticalsCarcinoma, Non-Small-Cell Lung
Start: 2018-12-26End: 2020-09-07Updated: 2022-01-24
Dabrafenib, Trametinib, and Spartalizumab for the Treatment of BRAF V600E or V600K Mutation Positive Stage IIIB/C/D Melanoma
TerminatedNCT04310397
M.D. Anderson Cancer CenterPathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Start: 2020-01-29End: 2023-10-09Updated: 2024-10-30
Study of Capmatinib and Spartalizumab/Placebo in Advanced NSCLC Patients With MET Exon 14 Skipping Mutations
TerminatedNCT04323436
Novartis PharmaceuticalsCarcinoma, Non-Small-Cell Lung
Start: 2020-08-19End: 2023-01-26Updated: 2024-10-09
Study of Efficacy and Safety of NIS793 (With and Without Spartalizumab) in Combination With SOC Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
TerminatedNCT04390763
Novartis PharmaceuticalsMetastatic Pancreatic Ductal Adenocarcinoma
Start: 2020-10-16End: 2024-05-02Updated: 2025-10-16
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
Active, not recruitingNCT04802876
SOLTI Breast Cancer Research GroupAnal Carcinoma, Carcinoma of Unknown Primary, Cervical Carcinoma +28
Start: 2021-04-12End: 2027-03-31Target: 184Updated: 2025-03-21
Combination of Capmatinib + Spartalizumab in Advanced Oesogastric Adenocarcinoma
SuspendedNCT05135845
Assistance Publique - Hôpitaux de ParisGastric Adenocarcinoma, Oesophageal Adenocarcinoma
Start: 2022-03-22End: 2025-10-31Target: 90Updated: 2023-02-03
Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.
Active, not recruitingNCT05201066
Novartis PharmaceuticalsLeukemia, Myelomonocytic, Chronic, Myelodysplastic Syndromes
Start: 2023-02-13End: 2028-02-14Updated: 2026-01-07

Phase 3

Related Papers

Molecular Therapy — Oncolytics2023-12-0127 citations
Regular and Young Investigator Award Abstracts2023-10-312 citations

12 more papers not shown