SONALA-001 (ALA) and MR-Guided Focused Ultrasound device (MRgFUS)

COMBINATION_PRODUCT2 trials

Sponsors

SonALAsense, Inc.

Conditions

Diffuse Intrinsic Pontine GliomaDiffuse Midline GliomaRecurrent GBM

Phase 1

A Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Subjects With Recurrent GBM

TerminatedNCT05370508

SonALAsense, Inc.Recurrent GBM

Start: 2023-02-06End: 2024-07-08Updated: 2024-07-26

Phase 2

A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG

SuspendedNCT05123534

SonALAsense, Inc.Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma

Start: 2022-08-12End: 2024-10-30Updated: 2024-09-19

Related Papers

1151 Sonodynamic Therapy (SDT) Using Intravenous 5-aminolevulinic Acid With MR-Guided Focused Ultrasound (MRgFUS) for the Treatment of Diffuse Intrinsic Pontine Gliomas in Pediatrics: Initial Safety and Outcomes of the Multicenter SDT-201 Trial

Neurosurgery2025-03-14

1147 Effects of Sonodynamic Therapy on Clonogenic Properties of Glioblastoma Cells

Neurosurgery2025-03-14

CTNI-74. SONODYNAMIC THERAPY (SDT) USING INTRAVENOUS 5-AMINOLEVULINIC ACID WITH NON-ABLATIVE FOCUSED ULTRASOUND FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS IN PEDIATRICS: INITIAL SAFETY AND OUTCOMES THE MULTICENTER SDT-201 TRIAL

Neuro-Oncology2024-11-011 citations

CTNI-76. A PHASE 1/2 DOSE ESCALATION AND EXPANSION STUDY OF SONODYNAMIC THERAPY WITH SONALA-001 IN COMBINATION WITH NON-ABLATIVE MR-GUIDED FOCUSED ULTRASOUND IN SUBJECTS WITH PROGRESSIVE OR RECURRENT GLIOBLASTOMA

Neuro-Oncology2024-11-01

TRLS-17. INTERIM CLINICAL, PHARMACOKINETIC, AND TECHNICAL REPORT OF A PHASE 2 STUDY OF SONODYNAMIC THERAPY (SDT) USING SONALA-001 TOGETHER WITH MR-GUIDED LOW-INTENSITY FOCUSED ULTRASOUND (MRGFUS) IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Neuro-Oncology2024-06-183 citations

DIPG-69. IN-VITRO DETERMINATION OF 5-AMINOLEVULINIC-ACID-TREATMENT EFFICACY IN PATIENT-DERIVED DIPG MODELS

Neuro-Oncology2024-06-18

A phase 1/2 dose escalation and expansion study of sonodynamic therapy with SONALA-001 in combination with Exablate 4000 Type 2.0 MR-guided focused ultrasound in patients with progressive or recurrent glioblastoma (rGBM).

Journal of Clinical Oncology2024-06-013 citations

Interim report of a phase 2 study of sonodynamic therapy (SDT) using SONALA-001 together with MR-guided low-intensity focused ultrasound (MRgFUS) in children with diffuse intrinsic pontine glioma (DIPG).

Journal of Clinical Oncology2024-06-011 citations

181 Initial Experience With Sonodynamic Therapy Using Low-Intensity Focused Ultrasound and ALA for Pediatric Patients With Diffuse Intrinsic Pontine Glioma

Neurosurgery2024-03-15

Phase 1/2, first-in-child study of sonodynamic therapy (SDT) using low intensity focused ultrasound and 5-aminolevulinic acid (ALA) for patients with diffuse intrinsic pontine glioma.

Journal of Clinical Oncology2023-06-017 citations