Sodium Zirconium Cyclosilicate (ZS)

DRUG2 trials

Sponsors

AstraZeneca

Conditions

Hyperkalemia

Phase 1

A Safety and Pharmacodynamic Study of Healthy Chinese Subjects Administered Sodium Zirconium Cyclosilicate (ZS)

CompletedNCT03283267

AstraZenecaHyperkalemia

Start: 2017-10-24End: 2017-11-23Updated: 2017-12-19

Phase 3

A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients.

CompletedNCT03303521

AstraZenecaHyperkalemia

Start: 2017-12-14End: 2018-11-07Updated: 2020-02-20

Related Papers

Hyperkalemia burden and treatment patterns in Chinese patients on hemodialysis: final analysis of a prospective multicenter cohort study (PRECEDE-K)

Renal Failure2024-09-092 citations

Hyperkalaemia prevalence and dialysis patterns in Chinese patients on haemodialysis: an interim analysis of a prospective cohort study (PRECEDE-K).

2023-08-093 citations

Evaluation of the effect of sodium zirconium cyclosilicate on arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with hyperkalaemia: protocol for the multicentre, randomised, controlled DIALIZE-Outcomes study

BMJ Open2023-05-017 citations

Course of Hyperkalemia in Patients on Hemodialysis

International Journal of Nephrology2022-04-284 citations

Potassium responses to sodium zirconium cyclosilicate in hyperkalemic hemodialysis patients: post-hoc analysis of DIALIZE

BMC Nephrology2022-02-0812 citations

Hypokalemia Events With Sodium Zirconium Cyclosilicate and Placebo in Hemodialysis Patients

Kidney International Reports2022-01-281 citations

Phase I Study of the Pharmacodynamics and Safety of Sodium Zirconium Cyclosilicate in Healthy Chinese Adults

Clinical Pharmacology in Drug Development2022-01-085 citations

Effectiveness of Sodium Zirconium Cyclosilicate in Hemodialysis Patients With Severe Hyperkalemia

Kidney International Reports2021-09-136 citations

MO214EVALUATION OF THE EFFECT OF A POTASSIUM BINDER ON ARRHYTHMIA-RELATED CARDIOVASCULAR OUTCOMES IN PATIENTS ON CHRONIC HAEMODIALYSIS WITH RECURRENT HYPERKALAEMIA: DESIGN AND RATIONALE FOR THE SODIUM ZIRCONIUM CYCLOSILICATE DIALIZE-OUTCOMES STUDY

Nephrology Dialysis Transplantation2021-05-01

P0220EFFECTIVENESS OF SODIUM ZIRCONIUM CYCLOSILICATE (SZC) IN HAEMODIALYSIS PATIENTS WITH SEVERE HYPERKALAEMIA IN THE DIALIZE STUDY

Nephrology Dialysis Transplantation2020-06-01

P0242SUBGROUP EFFICACY ANALYSIS OF SODIUM ZIRCONIUM CYCLOSILICATE (SZC) IN HYPERKALAEMIC HAEMODIALYSIS PATIENTS IN THE DIALIZE STUDY

Nephrology Dialysis Transplantation2020-06-01

A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia

Journal of the American Society of Nephrology2019-06-14142 citations