Sodium Zirconium Cyclosilicate
Sponsors
Vaestra Goetalandsregionen, ZS Pharma, Inc., AstraZeneca, University of California, Irvine, Michael Fu
Conditions
Acute HyperkalemiaCKDChronic Kidney DiseaseChronic Kidney DiseasesDiabetes Mellitus, Type 2Diet ModificationHeart FailureHeart Failure With Reduced Ejection Fraction
Phase 1
Phase 2
Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure
TerminatedNCT03532009
Start: 2018-06-26End: 2020-05-22Updated: 2021-06-15
OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure
Active, not recruitingNCT04789239
Start: 2021-09-01End: 2025-12-31Target: 110Updated: 2025-07-04
The ORTIZ Study: Optimising RASi Therapy With SZC
TerminatedNCT04983979
Start: 2022-06-17End: 2023-05-16Updated: 2025-06-08
OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure (OPRA-HF)
Active, not recruitingCTIS2024-511502-24-02
Start: 2021-08-18Target: 1Updated: 2024-08-14
Phase 3
Safety & Efficacy of Zirconium Silicate Dosed for 28 Days in Hyperkalemia.
CompletedNCT02088073
Start: 2014-03-31End: 2015-01-31Updated: 2018-12-07
Open-label Safety & Efficacy of ZS (Sodium Zirconium Cyclosilicate)10g qd to Extend Study ZS-004 in Hyperkalemia.
CompletedNCT02107092
Start: 2014-05-31End: 2015-08-31Updated: 2018-08-15
Open-label Safety and Efficacy of Sodium Zirconium Cyclosilicate for up to 12 Months
CompletedNCT02163499
Start: 2014-06-30End: 2016-11-30Updated: 2018-06-27
Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects
CompletedNCT04217590
Start: 2020-11-16End: 2022-01-03Updated: 2023-03-28
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
TerminatedNCT04727528
Start: 2021-03-22End: 2022-09-14Updated: 2023-10-06
Sodium Zirconium Cyclosilicate Lowers Hyperkalemia After Parathyroidectomy
CompletedNCT05382988
Start: 2016-11-30End: 2021-12-31Updated: 2022-05-19
Keeping RAASi Treatment With Optimal Potassium Control
RecruitingNCT06578533
Start: 2022-09-30End: 2026-07-30Target: 78Updated: 2024-08-29
A Clinical Trial to Define the Best Strategy for the Management of Heart Failure in Elderly Patients
RecruitingNCT06578078
Start: 2024-10-03End: 2026-12-30Target: 94Updated: 2026-03-04
Phase 4
Comparison of Potassium Binders in the ER
TerminatedNCT04585542
Start: 2020-10-20End: 2025-01-31Updated: 2026-04-22
Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone
CompletedNCT04676646
Start: 2021-03-08End: 2024-07-15Updated: 2025-07-09
Sodium Zirconium Cyclosilicate to Allow Liberal Fruit and Vegetable Intake for Patients With CKD Stage 3b and 4
RecruitingNCT06365684
Start: 2024-04-29End: 2025-05-01Target: 16Updated: 2025-03-06