Sodium Lactate

DRUG12 trials

Sponsors

Hvidovre Hospital, Assistance Publique Hopitaux De Paris, Centre Hospitalier Universitaire De Nice, Fakultni Nemocnice Plzen, University of California, Los Angeles

Conditions

Appetitive BehaviorBrain Injuries, TraumaticBrain RelaxationDiabetic keto-acidosisHypoglycemia UnawarenessIntracranial HypertensionMajor Depressive DisorderOsteoarthritis of the hip and knee

Phase 2

Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)

WithdrawnNCT02776488

University of California, Los AngelesBrain Injuries, Traumatic

Start: 2020-09-30End: 2026-06-30Updated: 2021-11-15

Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients With Major Depressive Disorder

Not yet recruitingNCT06168175

Centre Hospitalier Universitaire VaudoisMajor Depressive Disorder

Start: 2024-01-31End: 2028-01-31Target: 46Updated: 2023-12-13

Study SOLACE SEPSIS

RecruitingNCT06634069

University Hospital PilsenIntracranial Hypertension, Septic Shock

Start: 2024-11-24End: 2027-10-31Target: 40Updated: 2025-04-13

A Pilot, Randomized, Double-Blinded, Controlled Study of Hemodynamic and Acid Base Effects of 0.5M Sodium Lactate and 3% Saline Solutions in Septic Shock Patients

RecruitingCTIS2024-517927-37-00

Fakultni Nemocnice PlzenPatients suffering from septic shock who require fluid resuscitation.

Start: 2024-11-24Target: 40Updated: 2025-03-19

Sodium Lactate in Severe TBI

Not yet recruitingNCT06701760

University of California, Los AngelesTraumatic Brain Injury

Start: 2028-01-10End: 2038-07-01Target: 264Updated: 2026-01-16

Phase 3

Sodium Lactate and Brain Relaxation (LSD)

CompletedNCT04488874

Centre Hospitalier Universitaire de BesanconBrain Relaxation, Intracranial Hypertension, Sodium Lactate

Start: 2020-09-29End: 2023-06-30Updated: 2023-09-13

DASSOH - Systematic use of DDAVP to prevent serum sodium overcorrection in severe hyponatremia : a multicenter open-label randomized controlled trial

RecruitingCTIS2023-507254-32-00

Assistance Publique Hopitaux De ParisSevere hyponatremia and a high risk of rapid SNa overcorrection

Start: 2024-12-17Target: 260Updated: 2025-10-24

Phase 4

Randomized trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on recovery after total hip, total knee, and unicompartmental knee arthroplasty

CompletedCTIS2022-501221-21-00

Hvidovre HospitalOsteoarthritis of the hip and knee

Start: 2023-02-03End: 2025-04-06Target: 222Updated: 2024-12-03

Comparison of isotonic saline and Ringer lactate in the management of severe diabetic ketoacidosis: a double-blind randomized controlled trial.

RecruitingCTIS2024-511513-37-00

Centre Hospitalier Universitaire De NiceDiabetic keto-acidosis

Start: 2025-10-23Target: 300Updated: 2025-01-10

Unknown Phase

The Effect of Intravenous Lactate on Brain Lactate Concentrations During Hypoglycemia

CompletedNCT03286816

Radboud University Medical CenterType 1 Diabetes Mellitus With Hypoglycemia

Start: 2016-11-30End: 2017-08-31Updated: 2017-09-19

The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia

Radboud University Medical CenterHypoglycemia Unawareness, Type1diabetes

Start: 2018-06-11End: 2019-06-11Target: 10Updated: 2018-11-05

Effect of Oral Lactate Ingestion on Appetite Regulation

Not yet recruitingNCT06379815

Wilfrid Laurier UniversityAppetitive Behavior

Start: 2024-05-01End: 2024-08-31Target: 12Updated: 2024-04-23

Related Papers

Exogenous lactate infusion (ELI) in traumatic brain injury: higher dose is better?

Critical Care2025-04-144 citations

Clinical effectiveness of hypertonic sodium lactate infusion for intraoperative brain relaxation in patients undergoing scheduled craniotomy for supratentorial brain tumor resection: A study protocol of a single center double-blind randomized controlled phase II pilot trial

Medicine2022-10-07

Effect of lactate administration on cerebral blood flow during hypoglycemia in people with type 1 diabetes

BMJ Open Diabetes Research & Care2022-03-016 citations

Elevated brain glutamate levels in type 1 diabetes: correlations with glycaemic control and age of disease onset but not with hypoglycaemia awareness status.

2019-04-1921 citations