SMC with SP+AQ

DRUG2 trials

Sponsors

London School of Hygiene and Tropical Medicine

Conditions

Child, OnlyChildren, OnlyMalaria,Falciparum

Phase 3

Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)

CompletedNCT03143218

London School of Hygiene and Tropical MedicineChildren, Only, Malaria,Falciparum

Start: 2017-04-17End: 2020-03-31Updated: 2022-04-07

Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study

CompletedNCT04319380

London School of Hygiene and Tropical MedicineChild, Only, Malaria,Falciparum

Start: 2020-04-01End: 2022-03-31Updated: 2024-09-20

Related Papers

Clinical presentation of severe malaria in children who received the RTS,S/AS01E malaria vaccine, seasonal malaria chemoprevention or the combination of both interventions in Burkina Faso and Mali

Malaria Journal2026-07-22

Clinical presentation of severe malaria in children who received the RTS,S/AS01E malaria vaccine, seasonal malaria chemoprevention or the combination of both interventions in Burkina Faso and Mali.

2026-02-14

The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01<sub>E</sub>.

2025-02-061 citations

Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.

2023-09-01

Seasonal vaccination with RTS,S/AS01<sub>E</sub> vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial.

2023-08-2242 citations

The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

BMC Medicine2022-10-0729 citations

Impact of seasonal RTS,S/AS01E vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali

Malaria Journal2022-02-222 citations

The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine

Clinical Infectious Diseases2021-12-109 citations

Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention

New England Journal of Medicine2021-08-25215 citations

Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.

2021-05-05326 citations

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01<sub>E</sub>vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

BMJ Open2020-09-0116 citations

Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: Secondary analysis of a household-randomised, placebo-controlled trial in Houndé District, Burkina Faso and Bougouni District, Mali

PLoS Medicine2020-08-2151 citations

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults

The Journal of Infectious Diseases2020-07-1744 citations